{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T04:56:38Z","timestamp":1776056198576,"version":"3.50.1"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Metastatic tumors of the thyroid gland are rare in clinical practice. Clear cell renal cell carcinoma (ccRCC) is the most common primary site among metastatic thyroid carcinomas, accounting for 12% to 34% of all secondary thyroid tumors. Most secondary thyroid cancers have a poorer prognosis than primary papillary thyroid carcinoma. Therefore, the diagnosis and treatment of secondary thyroid tumors deserve attention. The diagnosis and treatment of secondary thyroid carcinoma pose significant challenges. We herein report a case of clear cell renal cell carcinoma metastasizing to the thyroid gland.<\/jats:p>","DOI":"10.3389\/fonc.2026.1752093","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T04:39:05Z","timestamp":1776055145000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clear cell renal cell carcinoma metastasizing to the thyroid gland: a case report"],"prefix":"10.3389","volume":"16","author":[{"given":"Zhengshi","family":"Xia","sequence":"first","affiliation":[{"name":"Department of Thyroid Surgery, The First Affiliated Hospital of Zhengzhou University","place":["Zhengzhou, Henan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuzhi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Thyroid Surgery, The First Affiliated Hospital of Zhengzhou University","place":["Zhengzhou, Henan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Thyroid Surgery, The First Affiliated Hospital of Zhengzhou University","place":["Zhengzhou, Henan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengfei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Thyroid Surgery, The First Affiliated Hospital of Zhengzhou University","place":["Zhengzhou, Henan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhua","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Thyroid Surgery, The First Affiliated Hospital of Zhengzhou University","place":["Zhengzhou, Henan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,13]]},"reference":[{"key":"B1","article-title":"Metastasis to the thyroid gland","volume":"79","author":"Nakhjavani","year":"2000","journal-title":"Cancer"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2104","DOI":"10.3390\/cancers12082104","article-title":"Novel targeted therapies for metastatic thyroid cancer-a comprehensive review","volume":"12","author":"Al-Jundi","year":"2020","journal-title":"Cancers (Basel)"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.7150\/jca.101395","article-title":"New horizons of biomarkers in metastatic thyroid cancer","volume":"16","author":"Cendra","year":"2025","journal-title":"J Cancer"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1350043","article-title":"Case report: Report of a rare encounter: metastasis of renal cell carcinoma to the thyroid","volume":"14","author":"Xu","year":"2024","journal-title":"Front Oncol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0b013e328359ff1f","article-title":"Surgical management of the lateral neck compartment for metastatic thyroid cancer","volume":"25","author":"Dralle","year":"2013","journal-title":"Curr Opin Oncol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"2510","DOI":"10.3390\/cancers15092510","article-title":"Thyroid hormone withdrawal versus recombinant human TSH as preparation for I-131 therapy in patients with metastatic thyroid cancer: a systematic review and meta-analysis","volume":"15","author":"Giovanella","year":"2023","journal-title":"Cancers (Basel)"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3978\/j.issn.2227-684X.2015.06.01","article-title":"Transaxillary single-incision robotic neck dissection for metastatic thyroid cancer","volume":"4","author":"Kang","year":"2015","journal-title":"Gland Surg"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1111\/ans.16482","article-title":"Thyroid gland metastasis from renal cell carcinoma: a case series and literature review","volume":"91","author":"Tjahjono","year":"2021","journal-title":"Anz J Surg"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.3.7.939","article-title":"Recurrent and\/or metastatic thyroid cancer: therapeutic options","volume":"3","author":"Karavitaki","year":"2002","journal-title":"Expert Opin Pharmacother"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2017.1340939","article-title":"Advances in small molecule therapy for treating metastatic thyroid cancer","volume":"18","author":"Krajewska","year":"2017","journal-title":"Expert Opin Pharmacother"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1177\/10507256251390877","article-title":"Executive summary of the 2025 American Thyroid Association management guidelines for adult patients with differentiated thyroid cancer","volume":"35","author":"Praw","year":"2025","journal-title":"Thyroid"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1097\/sla.0000000000003580","article-title":"The American Association of Endocrine Surgeons guidelines for the definitive surgical management of thyroid disease in adults","volume":"271","author":"Patel","year":"2020","journal-title":"Ann Surg"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.4158\/ep10111.Or","article-title":"Incidental radiologic finding of an anterior superior mediastinal mass masquerading as metastatic thyroid cancer in patients with treated thyroid cancer","volume":"17","author":"McCullen","year":"2011","journal-title":"Endocr Pract"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.2147\/ott.S49430","article-title":"Sorafenib in radioactive iodine-refractory well-differentiated metastatic thyroid cancer","volume":"7","author":"McFarland","year":"2014","journal-title":"Onco Targets Ther"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1080\/17446651.2022.2060819","article-title":"Predictive molecular pathology in metastatic thyroid cancer: the role of RET fusions","volume":"17","author":"Nacchio","year":"2022","journal-title":"Expert Rev Endocrinol Metab"},{"key":"B16","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1007\/s12020-020-02453-8","article-title":"Progression and dormancy in metastatic thyroid cancer: concepts and clinical implications","volume":"70","author":"Rajan","year":"2020","journal-title":"Endocrine"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007958.pub2","article-title":"Angiogenesis-inhibitors for metastatic thyroid cancer","volume":"2010","author":"Tan","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2013-0362","article-title":"Sorafenib in metastatic thyroid cancer: a systematic review","volume":"19","author":"Thomas","year":"2014","journal-title":"Oncologist"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-7-265","article-title":"Renal cell carcinoma metastasis to thyroid tumor: a case report and review of the literature","volume":"7","author":"Medas","year":"2013","journal-title":"J Med Case Rep"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2840130306","article-title":"Metastases to the thyroid gland: diagnosis by aspiration cytology","volume":"13","author":"Michelow","year":"1995","journal-title":"Diagn Cytopathol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1007\/s12672-024-00967-5","article-title":"Outcomes of thyroidectomy for secondary thyroid Malignancies, a single center experience","volume":"15","author":"Aydo\u011fdu","year":"2024","journal-title":"Discov Oncol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v7.i21.3474","article-title":"Characteristics of clear cell renal cell carcinoma metastases to the thyroid gland: a systematic review","volume":"7","author":"Khaddour","year":"2019","journal-title":"World J Clin cases"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-019-0307-2","article-title":"Therapeutic breakthroughs for metastatic thyroid cancer","volume":"16","author":"Tiedje","year":"2020","journal-title":"Nat Rev Endocrinol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1055\/a-1023-4214","article-title":"Anti-tumor activity and safety of multikinase inhibitors in advanced and\/or metastatic thyroid cancer: a systematic review and network meta-analysis of randomized controlled trials","volume":"52","author":"Tsoli","year":"2020","journal-title":"Horm Metab Res"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1752093\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T04:39:14Z","timestamp":1776055154000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1752093\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,13]]},"references-count":24,"alternative-id":["10.3389\/fonc.2026.1752093"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2026.1752093","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,13]]},"article-number":"1752093"}}