{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T13:51:53Z","timestamp":1769262713257,"version":"3.49.0"},"reference-count":22,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Primary intracranial myxofibrosarcoma (MFS) is an exceedingly rare mesenchymal malignancy, with only a few cases reported. We report a 34-year-old male with a right frontal lobe MFS who subsequently developed two non-contiguous recurrences in the right temporal and left frontal lobes. Histopathological examination revealed a stepwise progression from low- to intermediate- to high-grade disease, accompanied by progressively increasing Ki-67 labeling indices. Notably, the pattern of spatially separate recurrences suggests the possibility of cerebrospinal fluid\u2013mediated dissemination. This case highlights the aggressive and heterogeneous nature of intracranial MFS and underscores the importance of long-term, comprehensive follow-up to detect recurrences, particularly at non-contiguous sites.<\/jats:p>","DOI":"10.3389\/fonc.2026.1755019","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T06:48:29Z","timestamp":1769150909000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Recurrent primary intracranial myxofibrosarcoma: a case report and review of the literature"],"prefix":"10.3389","volume":"16","author":[{"given":"Shuting","family":"Wen","sequence":"first","affiliation":[{"name":"Department of Radiology, Second People\u2019s Hospital of Yuhang District","place":["Hangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengqi","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Zhongnan Hospital of Wuhan University","place":["Wuhan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rufang","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Radiology, Zhongnan Hospital of Wuhan University","place":["Wuhan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology, Zhongnan Hospital of Wuhan University","place":["Wuhan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soc.2016.05.008","article-title":"Myxofibrosarcoma","volume":"25","author":"Roland","year":"2016","journal-title":"Surg Oncol Clin N Am"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13193022","article-title":"Biology and management of high-grade myxofibrosarcoma: state of the art and future perspectives","volume":"13","author":"Nishio","year":"2023","journal-title":"Diagnostics (Basel)"},{"key":"B3","doi-asserted-by":"publisher","first-page":"2765","DOI":"10.1038\/s41467-018-03891-9","article-title":"Integrated genetic and epigenetic analysis of myxofibrosarcoma","volume":"9","author":"Ogura","year":"2018","journal-title":"Nat Commun"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1977.tb00410.x","article-title":"Myxofibrosarcoma. 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