{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T05:09:17Z","timestamp":1779340157571,"version":"3.51.4"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Myxopapillary ependymoma (MPE), a histological variant of ependymoma, is characterized by a radial arrangement of spindled or epithelioid tumor cells surrounding blood vessels, accompanied by perivascular myxoid changes and microcyst formation. MPE typically occurs in young adults, predominantly in the conus medullaris, cauda equina, and filum terminale. However, primary intracranial MPEs, especially those arising in the cerebral parenchyma, are exceptionally rare. Here, we present two cases of isolated MPEs located in the frontal lobe to underscore their extraordinary rarity. We provide a comprehensive analysis of their clinical characteristics, imaging findings, and pathological features to deepen the understanding and recognition of this rare entity.<\/jats:p>","DOI":"10.3389\/fonc.2026.1763325","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T04:37:30Z","timestamp":1779338250000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Primary intracranial myxopapillary ependymoma: two case reports and literature review"],"prefix":"10.3389","volume":"16","author":[{"given":"Lan","family":"Zhong","sequence":"first","affiliation":[{"name":"Department of Pathology, The General Hospital of Western Theater Command","place":["Chengdu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pathology, The General Hospital of Western Theater Command","place":["Chengdu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiyuan","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Pathology, The General Hospital of Western Theater Command","place":["Chengdu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongjuan","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Pathology, The General Hospital of Western Theater Command","place":["Chengdu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feizhou","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Radiology, The General Hospital of Western Theater Command","place":["Chengdu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuande","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology, The General Hospital of Western Theater Command","place":["Chengdu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihua","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology, The General Hospital of Western Theater Command","place":["Chengdu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, The General Hospital of Western Theater Command","place":["Chengdu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1545-1","article-title":"The 2016 World Health Organization classification of tumors of the central nervous system: a summary","volume":"131","author":"Louis","year":"2016","journal-title":"Acta Neuropathol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noab106","article-title":"The 2021 WHO classification of tumors of the central nervous system: a summary","volume":"23","author":"Louis","year":"2021","journal-title":"Neuro Oncol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-021-03717-7","article-title":"Clinical characteristics and long-term surgical outcome of spinal myxopapillary ependymoma: a French cohort of 101 patients","volume":"152","author":"Montero","year":"2021","journal-title":"J Neuro-Oncol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-016-2167-0","article-title":"Myxopapillary ependymoma: a SEER analysis of epidemiology and outcomes","volume":"129","author":"Bates","year":"2016","journal-title":"J Neuro-Oncol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/bf00249392","article-title":"Histologic prognostic factors in ependymoma","volume":"7","author":"Schiffer","year":"1991","journal-title":"Childs Nerv Syst"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21608","article-title":"Identification of relevant prognostic histopathologic features in 69 intracranial ependymomas, excluding myxopapillary ependymomas and subependymomas","volume":"106","author":"Kurt","year":"2006","journal-title":"Cancer"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2014.08.006","article-title":"Outcome predictors in the management of spinal myxopapillary ependymoma: an integrative survival analysis","volume":"83","author":"Kukreja","year":"2015","journal-title":"World Neurosurg"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nou293","article-title":"Long-term outcome of patients with spinal myxopapillary ependymoma: treatment results from the MD Anderson Cancer Center and institutions from the Rare Cancer Network","volume":"17","author":"Weber","year":"2015","journal-title":"Neuro Oncol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"59","DOI":"10.3171\/ped.2005.102.1.0059","article-title":"The high incidence of tumor dissemination in myxopapillary ependymoma in pediatric patients. 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