{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T07:57:02Z","timestamp":1781596622692,"version":"3.54.5"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Primary diffuse large B-cell lymphoma (DLBCL) of the lip is a rare subtype of extranodal non-Hodgkin lymphoma that presents a diagnostic challenge due to its infrequent location and nonspecific clinical symptoms. The early suspicion of this diagnosis is often delayed because of its overlap with benign inflammation\/infection, such as abscesses and mucoceles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>This report describes a 65-year-old male with worsening swelling of the upper lip that was initially diagnosed as a maxillary space infection. Imaging studies, including ultrasound and MRI, showed a poorly defined mass, and an axial biopsy with immunohistochemistry confirmed a diagnosis of the germinal center B-cell (GCB) subtype of DLBCL. The patient was ultimately treated successfully with R-CHOP chemotherapy and achieved complete remission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case illustrates both the importance of considering lymphoma in the differential diagnosis of a lip lesion that has persisted and requires ongoing clinical evaluation, as well as the benefit of multidisciplinary care for appropriate diagnosis and timely management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1763767","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T05:37:10Z","timestamp":1780897030000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Primary diffuse large b-cell lymphoma of the lip: a case report and literature 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