{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T14:43:54Z","timestamp":1772462634469,"version":"3.50.1"},"reference-count":9,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults. It is characterized by the accumulation of mature monoclonal B lymphocytes. While native kidney infiltration in CLL is relatively common and typically subclinical, involvement of a transplanted kidney is exceedingly rare and may have profound clinical implications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Summary<\/jats:title>\n                    <jats:p>We present the case of a 65-year-old woman with end-stage renal disease secondary to hypertension and diabetes mellitus who underwent kidney transplantation in 2016. Several years later, she was diagnosed with Rai stage I CLL following imaging and histopathologic analysis of axillary lymphadenopathy. Despite an initially indolent course, she developed worsening renal function in 2025. A biopsy of the allograft revealed CLL infiltration consistent with her prior nodal disease. The patient was started on Zanubrutinib, a Bruton tyrosine kinase inhibitor (BTKi), with stabilization of renal function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case highlights a rare and clinically significant presentation of CLL involving a renal allograft. As the therapeutic landscape evolves with the advent of BTK inhibitors, prompt recognition and treatment of extranodal CLL involvement may improve outcomes. This case represents only the second reported instance of successful BTKi use for CLL infiltration in a kidney transplant recipient.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1765255","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T05:16:00Z","timestamp":1770009360000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: renal allograft infiltration by chronic lymphocytic leukemia successfully treated with zanubrutinib"],"prefix":"10.3389","volume":"16","author":[{"given":"Brian","family":"Abboud","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, SSM Health-Saint Louis University School of Medicine","place":["Saint Louis, MO, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nehemias Guevara","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Division of Hematology, Oncology and Bone Marrow Transplant, Department of Internal Medicine, SSM-Health Saint Louis University School of Medicine","place":["St. Louis, MO, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arslan","family":"Babar","sequence":"additional","affiliation":[{"name":"Division of Hematology, Oncology and Bone Marrow Transplant, Department of Internal Medicine, SSM-Health Saint Louis University School of Medicine","place":["St. Louis, MO, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noemy","family":"Coreas","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Salvadoran Social Security Institute (ISSS), University of El Salvador (UES)","place":["San Salvador, El Salvador"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Robbins","sequence":"additional","affiliation":[{"name":"Department of Pathology, SSM-Health Saint Louis University School of Medicine","place":["Saint Louis, MO, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranju","family":"Kunwor","sequence":"additional","affiliation":[{"name":"Division of Hematology, Oncology and Bone Marrow Transplant, Department of Internal Medicine, SSM-Health Saint Louis University School of Medicine","place":["St. Louis, MO, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21708","article-title":"Cancer statistics, 2022","volume":"72","author":"Siegel","year":"2022","journal-title":"CA Cancer J Clin"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra041720","article-title":"Chronic lymphocytic leukemia","volume":"352","author":"Chiorazzi","year":"2005","journal-title":"N Engl J 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