{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T15:36:57Z","timestamp":1789400217041,"version":"build-2803163510"},"reference-count":16,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To compare the differences in dosimetry and toxicities between Magnetic Resonance Imaging (MRI) and Computed Tomography (CT)-guided intracavitary and interstitial implantation for locally advanced cervical cancer, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We analyzed 40 cases of locally advanced cervical cancer admitted to our hospital from January 2023 to September 2024. Patients underwent CT-guided intracavitary and interstitial implantation followed by MRI scanning. We compared the volume of HR-CTV and IR-CTV, the dosimetric differences of HR-CTV D\n                      <jats:sub>90<\/jats:sub>\n                      and IR-CTV D\n                      <jats:sub>90<\/jats:sub>\n                      , and the dosimetric differences of D\n                      <jats:sub>2cc<\/jats:sub>\n                      for the bladder, rectum, and small intestine under the two localization methods.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean HR-CTV and IR-CTV volumes were larger using CT guidance compared with MRI guidance (P&amp;lt;0.05), the differences were statistically significant. The HR-CTV D\n                      <jats:sub>90<\/jats:sub>\n                      and IR-CTV D\n                      <jats:sub>90<\/jats:sub>\n                      were smaller using CT than MRI guidance. The difference was statistically significant (P&amp;lt;0.05). There was a statistically significant difference in the rectum D\n                      <jats:sub>2cc<\/jats:sub>\n                      between CT and MRI guidance (P&amp;lt;0.05), while there was no statistically significant difference for the D\n                      <jats:sub>2cc<\/jats:sub>\n                      of the bladder and small intestine between the two methods (P&amp;gt;0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Intracavitary and interstitial implantation under MRI guidance can significantly improve HR-CTV and IR-CTV D\n                      <jats:sub>90<\/jats:sub>\n                      with reduced target volume and good protection of the rectum, and there is no significant difference for the bladder and small intestine.\n                    <\/jats:p>\n                  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