{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T06:02:20Z","timestamp":1774245740859,"version":"3.50.1"},"reference-count":11,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Differentiating suspicious lesions presents a clinical challenge due to overlapping characteristics among benign, malignant, primary, and secondary pathologies, often leading to diagnostic errors and inappropriate treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>We report on a 54-year-old patient with triple-negative breast cancer (TNBC) who, during postoperative surveillance, was found to have pancreatic lesions. Although initial imaging and biopsy suggested adenocarcinoma, surgical excision and subsequent histopathological examination revealed chronic pancreatitis with atypical hyperplasia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case highlights the limitations of preoperative diagnostics and the complexity of distinguishing treatment-related injury from malignant recurrence, particularly in patients with prior exposure to radiotherapy and immunotherapy. To mitigate overtreatment, we advocate for a diagnostic paradigm that integrates systematic screening, advanced molecular profiling (e.g., next-generation sequencing), and a rigorous, multidisciplinary evaluation for all cancer survivors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1767121","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T05:20:49Z","timestamp":1774243249000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Discordant pancreatic inflammatory pseudotumor in a breast cancer survivor \u2013 a diagnostic dilemma"],"prefix":"10.3389","volume":"16","author":[{"given":"Zhe","family":"Cao","sequence":"first","affiliation":[{"name":"Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohong","family":"Lyu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyue","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taiping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.4251\/wjgo.v6.i10.381","article-title":"Metastatic tumors to the pancreas: the role of surgery","volume":"6","author":"Sperti","year":"2014","journal-title":"World J Gastrointest Oncol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1055\/a-1193-4954","article-title":"Contrast-enhanced harmonic versus standard endoscopic ultrasound-guided fine-needle aspiration in solid pancreatic lesions: a single-center prospective randomized trial","volume":"52","author":"Seicean","year":"2020","journal-title":"Endoscopy"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2018.6","article-title":"Using immunotherapy to boost the abscopal effect","volume":"18","author":"Ngwa","year":"2018","journal-title":"Nat Rev Cancer"},{"key":"B4","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.currproblcancer.2015.10.001","article-title":"The immune mechanisms of abscopal effect in radiation therapy","volume":"40","author":"Grass","year":"2016","journal-title":"Curr Probl Cancer"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3958","article-title":"The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence","volume":"15","author":"Barker","year":"2015","journal-title":"Nat Rev Cancer"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2025.01.010","article-title":"PAI-1-driven SFRP2high cancer-associated fibroblasts hijack the abscopal effect of radioimmunotherapy","volume":"43","author":"Zhang","year":"2025","journal-title":"Cancer Cell"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106663","article-title":"Abscopal effect in radioimmunotherapy","volume":"85","author":"Ashrafizadeh","year":"2020","journal-title":"Int Immunopharmacol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-26-305-234","article-title":"Whole body irradiation; 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