{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:55:17Z","timestamp":1781585717828,"version":"3.54.5"},"reference-count":13,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>\n                    We report a case of isolated splenic littoral cell angioma (LCA) in a 9-year-old male child, who was admitted for surgical treatment after an incidental discovery of a splenic space-occupying lesion during a physical examination one year prior at an external hospital(no significant reduction on follow-up). The child had no specific clinical symptoms, with only a slightly elevated platelet count (454\u00d710\n                    <jats:sup>9<\/jats:sup>\n                    \/L) and normal results of other laboratory and auxiliary examinations. Abdominal computed tomography (CT) showed a round-like hypodense mass (4.8 cm\u00d74.8 cm\u00d75.3 cm) in the upper pole of the spleen (plain CT value: ~43 HU). On enhanced CT, the mass exhibited characteristic \u201cfireball-like\u201d enhancement in the arterial phase (CT value: ~182 HU), continuous progressive enhancement in the portal venous phase (CT value: ~133 HU), and uniform density with mild attenuation in the delayed phase (CT value: ~98 HU), remaining slightly hyperdense relative to the normal spleen. Laparoscopic partial splenectomy was performed, and pathological examination combined with immunohistochemistry (CD31+, CD34+, CD68+, CD8+, SMA+, CD163+; Ki67: ~7%; D2-40-, CD21-, CD3-, CD20-) confirmed the diagnosis of LCA. No recurrence was observed at 3-month and 6-month postoperative follow-up. LCA is a rare primary splenic vascular tumor, especially uncommon as an isolated lesion in children. Its clinical manifestations are nonspecific, and CT enhancement features have important indicative value. Definitive diagnosis relies on pathology, and surgical resection yields a favorable prognosis.\n                  <\/jats:p>","DOI":"10.3389\/fonc.2026.1770088","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:29:38Z","timestamp":1781584178000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Isolated splenic littoral cell angioma in a child: a case report"],"prefix":"10.3389","volume":"16","author":[{"given":"Huihui","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Radiology, Anhui Provincial Children\u2019s Hospital","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Anhui Provincial Children\u2019s Hospital","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longxiu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Anhui Provincial Children\u2019s Hospital","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,16]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","DOI":"10.1097\/00000478-199111000-00001","article-title":"Littoral cell angioma. A novel splenic vascular lesion demonstrating histiocytic differentiation","volume":"15","author":"Falk","year":"1991","journal-title":"Am J Surg Pathol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.790332","article-title":"Clinical landscape of littoral cell angioma in the spleen based on a comprehensive analysis","volume":"12","author":"Wang","year":"2022","journal-title":"Front Oncol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2024.1473930","article-title":"Littoral cell angioma of a huge spleen with peripheral blood pancytopenia in a 14-year-old boy: a case report and review of the literature","volume":"12","author":"Gao","year":"2024","journal-title":"Front Pediatr"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000037550","article-title":"Littoral cell angioma of the spleen: A study of 10 cases case series and literature review","volume":"103","author":"Shen","year":"2024","journal-title":"Med (Baltimore)"},{"key":"B5","article-title":"Littoral cell angioma discovered after splenectomy in a patient with non-Hodgkin lymphoma and melanoma. Case report and review","volume":"12","author":"Schotte","year":"2023","journal-title":"Ann Ital Chir"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.21037\/qims-22-897","article-title":"Multimodality imaging findings of splenic littoral cell angioma: a case description and analysis of literature","volume":"13","author":"Zeng","year":"2023","journal-title":"Quant Imaging Med Surg"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2024.1383015","article-title":"Case report and literature review: Asymptomatic littoral cell angioma in a 3-year-old girl","volume":"12","author":"Mou","year":"2024","journal-title":"Front Pediatr"},{"key":"B8","article-title":"Littoral cell angioma of spleen: a clinicopathologic study of 17 cases","volume":"36","author":"Bi","year":"2007","journal-title":"Zhonghua Bing Li Xue Za Zhi"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v12.i11.1909","article-title":"Splenic hamartomas in children","volume":"12","author":"Milickovic","year":"2024","journal-title":"World J Clin cases"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-024-06041-0","article-title":"Imaging features of pediatric angiosarcomas: clinical, pathologic, and radiological review","volume":"54","author":"Almushayqih","year":"2024","journal-title":"Pediatr Radiol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-020-04692-3","article-title":"Imaging features of pathologically proven pediatric splenic masses","volume":"50","author":"Boehnke","year":"2020","journal-title":"Pediatr Radiol"},{"key":"B12","article-title":"Massive splenomegaly correlates with Malignancy: 180 cases of splenic littoral cell tumors in the world literature","volume":"69","author":"Sarandria","year":"2014","journal-title":"Minerva Chir"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2013.092460","article-title":"Long-term risks after splenectomy among 8149 cancer-free American veterans: a cohort study with up to 27 years follow-up","volume":"99","author":"Kristinsson","year":"2014","journal-title":"Haematologica"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1770088\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:29:41Z","timestamp":1781584181000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1770088\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,16]]},"references-count":13,"alternative-id":["10.3389\/fonc.2026.1770088"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2026.1770088","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,16]]},"article-number":"1770088"}}