{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:22:18Z","timestamp":1787026938722,"version":"build-2736575974"},"reference-count":13,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Patient concerns<\/jats:title>\n                    <jats:p>A 70-year-old man with a primary tracheal adenoid cystic carcinoma (TACC) located at 5 cm of the tracheal process.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>We adopted bronchoscopic ablation technology, including cryotherapy of probe tumor reduction and thermal ablation, which lasted for 7 years. After that, flexible mechanical tumor reduction was used to remove the tumor, and para-toluenesulfonamide (PTS) was injected to treat any residual tumors. During the treatment, we found that scarring-induced stenosis of the trachea near the superior aspect of the tumor, under these circumstances, we performed bronchoscopic laser treatment to remove scar tissue and relieve central airway obstruction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcomes<\/jats:title>\n                    <jats:p>The combined use of bronchoscopic laser treatment and PTS injection represents a promising treatment, especially suitable for patients who are not suitable for surgical removal. This case highlights the importance of individualized treatment strategies in managing complex airway obstruction, improving the quality of life of patients, and providing symptom relief for patients with advanced tumors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1772650","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T15:57:59Z","timestamp":1773763079000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: Long-term survival of adenoid cystic carcinoma with central airway stenosis treated by bronchoscopic ablation combined with para-toluenesulfonamide injection"],"prefix":"10.3389","volume":"16","author":[{"given":"Yedan","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Respiratory & Critical Care Medicine, Tianjin Chest Hospital","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Respiratory & Critical Care Medicine, Tianjin Chest Hospital","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.thorsurg.2024.09.008","article-title":"Management of primary tracheal tumors","volume":"35","author":"Schweiger","year":"2025","journal-title":"Thorac Surg Clinics"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/ajco.13162","article-title":"Tracheo-bronchial adenoid cystic carcinoma: a retrospective study","volume":"15","author":"Ning","year":"2019","journal-title":"Asia Pac J Clin Oncol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s13014-021-01770-0","article-title":"Clinical features, treatment 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intratumoral injection on non-small cell lung carcinoma with severe central airway obstruction: A multi-center, non-randomized, single-arm, open-label trial","volume":"98","author":"Li","year":"2016","journal-title":"Lung Cancer"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2018.03.70","article-title":"Effects of para-toluenesulfonamide intratumoral injection on pulmonary adenoid cystic carcinoma complicating with severe central airway obstruction: a 5-year follow-up study","volume":"10","author":"Guan","year":"2018","journal-title":"J Thorac Dis"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-5231(05)70131-3","article-title":"Cryotheray electrocautery and brachyteray","volume":"20","author":"Sheski","year":"1999","journal-title":"Clinics Chest Med"},{"key":"B13","doi-asserted-by":"publisher","first-page":"106582","DOI":"10.1016\/j.rmed.2021.106582","article-title":"Multi-disciplinary management of patients with benign airway strictures: A 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