{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T06:07:34Z","timestamp":1779084454944,"version":"3.51.4"},"reference-count":9,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Tracheoesophageal fistula with esophageal atresia (TEF\/EA) carries long-term gastrointestinal morbidity, including strictures, gastroesophageal reflux disease (GERD), and dysmotility, all of which predispose to chronic inflammation. Gastric signet-ring-cell adenocarcinoma (SRC) is rare in young adults and unusual in the context of congenital foregut anomalies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>A female in her twenties with repaired TEF\/EA had progressive dysphagia, recurrent food impactions, and severe distal esophageal stricture requiring frequent dilations. During routine surveillance esophagogastroduodenoscopy (EGD), SRC was incidentally identified. Biopsy handling errors, multiple specimens placed on a single slide labeled \u201cstomach\u201d obscured precise tumor localization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Management and outcomes<\/jats:title>\n                    <jats:p>Staging PET-CT showed no metastatic disease. A hereditary cancer panel (ATM, CDH1, CTNNA1, MLH1, MSH2, PMS2, TP53) was negative. Given uncertain tumor location and negative imaging, the patient elected endoscopic surveillance over total gastrectomy. An advanced endoscopist successfully traversed and treated the high-risk stricture, restoring patency and eliminating need for repeat dilations. Over 12 months, serial EGDs demonstrated no residual or recurrent malignancy, and the patient reported marked functional and psychosocial improvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case highlights the interplay of congenital foregut anomalies, chronic inflammation, and SRC development, and underscores the critical importance of meticulous biopsy handling and personalized endoscopic care. Tailored surveillance may be appropriate in select early-stage SRC cases where localization is uncertain and imaging is negative.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1774491","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T05:40:51Z","timestamp":1779082851000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: gastric signet-ring-cell adenocarcinoma in a young adult with tracheoesophageal fistula\/esophageal atresia and complex gastrointestinal history"],"prefix":"10.3389","volume":"16","author":[{"given":"Amira","family":"Katrib","sequence":"first","affiliation":[{"name":"Rocky Vista University","place":["Ivins, UT, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asis","family":"Babun","sequence":"additional","affiliation":[{"name":"Rocky Vista University","place":["Ivins, UT, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Wong","sequence":"additional","affiliation":[{"name":"Rocky Vista University","place":["Ivins, UT, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amberly","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Rocky Vista University","place":["Ivins, UT, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center","place":["New York, NY, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sempedsurg.2022.151231","article-title":"Anatomy and embryology of tracheo-esophageal fistula","volume":"31","author":"Durkin","year":"2022","journal-title":"Semin Pediatr Surg"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2022.07.008","article-title":"Esophageal atresia and tracheoesophageal fistula: Overview and considerations for the general surgeon","volume":"102","author":"Walk","year":"2022","journal-title":"Surg Clin North Am"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(03)00110-6","article-title":"Long-term analysis of children with esophageal atresia and tracheoesophageal fistula","volume":"38","author":"Little","year":"2003","journal-title":"J Pediatr Surg"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/nature01322","article-title":"Inflammation and cancer","volume":"420","author":"Coussens","year":"2002","journal-title":"Nature"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1473798","article-title":"Prognostic prediction and treatment options for gastric signet ring cell carcinoma: A SEER database analysis","volume":"14","author":"Yu","year":"2024","journal-title":"Front Oncol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-011-0434-6","article-title":"Gastric acid induces mitochondrial superoxide production and lipid peroxidation in gastric epithelial cells","volume":"46","author":"Matsui","year":"2011","journal-title":"J Gastroenterol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1517\/14740338.2016.1118050","article-title":"Safety of proton pump inhibitors and risk of gastric cancers: review of literature and pathophysiological mechanisms","volume":"15","author":"Ko","year":"2016","journal-title":"Expert Opin Drug Saf"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1244400","article-title":"Long-term proton pump inhibitors use and its association with premalignant gastric lesions: a systematic review and meta-analysis","volume":"14","author":"Zheng","year":"2023","journal-title":"Front Pharmacol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-024-16117-8","article-title":"Disappearing signet ring cell adenocarcinoma in gastric cancer patients","volume":"31","author":"Sreeram","year":"2024","journal-title":"Ann Surg Oncol"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1774491\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T05:40:51Z","timestamp":1779082851000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1774491\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,18]]},"references-count":9,"alternative-id":["10.3389\/fonc.2026.1774491"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2026.1774491","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,18]]},"article-number":"1774491"}}