{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T06:40:51Z","timestamp":1772692851565,"version":"3.50.1"},"reference-count":14,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cardiac metastasis from cervical cancer is rare and often presents with nonspecific symptoms, leading to diagnostic delays. This case highlights the role of myocardial contrast echocardiography (MCE) in detecting such metastases in long-term cervical cancer survivors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>A 63-year-old female with a history of cervical cancer treated 11 years ago presented with thrombocytopenia and respiratory symptoms. Imaging revealed a mobile mass in the right ventricle extending into the pulmonary artery. MCE showed peripheral rim enhancement, indicative of a necrotic malignant tumor, confirmed as metastatic squamous cell carcinoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Therapeutic intervention<\/jats:title>\n                    <jats:p>The patient underwent surgical resection of the right ventricular mass and tricuspid valvuloplasty. Her thrombocytopenia resolved post-surgery, and no further oncological treatment was needed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MCE is a valuable tool for diagnosing cardiac metastases, especially in cervical cancer survivors. This case underscores the need for long-term follow-up and imaging surveillance due to the risk of delayed and atypical metastasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1774949","type":"journal-article","created":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T05:25:50Z","timestamp":1772688350000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: A case of right ventricular metastasis from cervical cancer presenting with thrombocytopenia: the role of echocardiography and myocardial contrast echocardiography"],"prefix":"10.3389","volume":"16","author":[{"given":"Qian","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Ultrasound, Aerospace Center Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Radiology, Aerospace Center Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liming","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Aerospace Center Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Aerospace Center Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haijun","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Aerospace Center Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13778-6","article-title":"Cervical cancer","volume":"361","author":"Waggoner","year":"2003","journal-title":"Lancet"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(92)90310-f","article-title":"Superficially invasive squamous cell carcinoma of the cervix","volume":"45","author":"Copeland","year":"1992","journal-title":"Gynecol Oncol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1080\/01443615.2023.2181690","article-title":"Incidence, prognostic factors and a nomogram of cervical cancer with distant organ metastasis: a SEER-based study","volume":"43","author":"Shan","year":"2023","journal-title":"J Obstet Gynaecol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/s00066-024-02274-y","article-title":"Cardiac metastasis in uterine cervical cancer: A systematic review and case study","volume":"201","author":"Simek","year":"2025","journal-title":"Strahlenther Onkol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2018.10.004","article-title":"Too many women are dying from cervix cancer: Problems and solutions","volume":"151","author":"Gaffney","year":"2018","journal-title":"Gynecol Oncol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2016.27.e43","article-title":"Advances in diagnosis and treatment of metastatic cervical cancer","volume":"27","author":"Li","year":"2016","journal-title":"J Gynecol Oncol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"e62530","DOI":"10.7759\/cureus.62530","article-title":"A rare encounter with unusual metastasis: metastatic right ventricular tumor secondary to cervical cancer","volume":"16","author":"Nnadi","year":"2024","journal-title":"Cureus"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-019-0662-1","article-title":"Cardiac tumors: clinical presentation, diagnosis, and management","volume":"20","author":"Poterucha","year":"2019","journal-title":"Curr Treat Options Oncol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/s0828-282x(06)70247-1","article-title":"A 30-year analysis of cardiac neoplasms at autopsy","volume":"22","author":"Morphet","year":"2006","journal-title":"Can J Cardiol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1111\/echo.14597","article-title":"Clinical diagnostic value of contrast-enhanced ultrasonography in the diagnosis of cardiac masses: A pilot study","volume":"37","author":"Wang","year":"2020","journal-title":"Echocardiography"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1093\/ehjci\/jex182","article-title":"EACVI Scientific Documents Committee for 2014\u201316 and 2016\u201318; EACVI Scientific Documents Committee for 2014\u201316 and 2016\u201318. 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