{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:00:42Z","timestamp":1780470042612,"version":"3.54.1"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Cervical squamous cell carcinoma has been proven to be associated with human papillomavirus(HPV) infection, while the etiology of fallopian tube squamous cell carcinoma remains unclear and there are few literature reports. Clinically, concurrent cases of the two malignancies are even more rare. A female patient presented to our hospital with irregular vaginal bleeding. She underwent hysteroscopic surgery, and the postoperative pathology indicated cervical cancer. She subsequently received laparoscopic surgery, and postoperative pathology unexpectedly confirmed squamous cell carcinoma of the fallopian tube. We speculate that this represents a case of HPV-associated double primary squamous cell carcinomas. At present, the patient\u2019s general condition is stable after systematic treatment. This case reminds us to further understand the relationship between HPV infection and gynecological malignancies, as well as the benefits of rational application of opportunistic salpingectomy (OS), and we should strive for early diagnosis and treatment of tumors.<\/jats:p>","DOI":"10.3389\/fonc.2026.1776043","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:01:48Z","timestamp":1780466508000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Synchronous primary HPV-associated squamous cell carcinomas of the cervix and fallopian tube: a case report"],"prefix":"10.3389","volume":"16","author":[{"given":"Juan","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Gynecology, Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine","place":["Zhuhai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changqian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine","place":["Zhuhai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfang","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Pathology, Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine","place":["Zhuhai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine","place":["Zhuhai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"428","DOI":"10.3892\/ol.2023.14014","article-title":"Multiple synchronous primary Malignant neoplasms: a case report and literature review","volume":"26","author":"Hao","year":"2023","journal-title":"Oncol Lett"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1177\/0300060519876792","article-title":"Rare case of uterine neoplasm: cervical sarcoma with endometrial carcinoma","volume":"48","author":"Ma","year":"2020","journal-title":"J Int Med Res"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/465162","article-title":"The association between primary endometrioid carcinoma of the ovary and synchronous Malignancy of the endometrium","volume":"2010","author":"van Niekerk","year":"2010","journal-title":"Obstet Gynecol Int"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-010-1672-1","article-title":"Unusual form of superficial spreading squamous cell carcinoma of cervix involving the endometrium, bilateral tubes and ovaries: a case report with literature review","volume":"283","author":"Gungor","year":"2011","journal-title":"Arch Gynecol Obstet"},{"key":"B5","volume-title":"Obstetrics and gynecology","author":"Feng","year":"2010"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/s0039-6109(16)41439-8","article-title":"Carcinoma of the fallopian tube","volume":"58","author":"Sedlis","year":"1978","journal-title":"Surg Clin North Am"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2017.10.036","article-title":"Aberrant Pax-8 expression in well-differentiated papillary mesothelioma and Malignant mesothelioma of the peritoneum: a clinicopathologic study","volume":"72","author":"Xing","year":"2018","journal-title":"Hum Pathol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/srep08924","article-title":"Wilms' tumor 1 (WT1) expression and prognosis in solid cancer patients: a systematic review and meta-analysis","volume":"5","author":"Qi","year":"2015","journal-title":"Sci Rep"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2014.058","article-title":"Prognostic significance of retroperitoneal lymphadenectomy, preoperative neutrophil lymphocyte ratio and platelet lymphocyte ratio in primary fallopian tube carcinoma: a multicenter study","volume":"47","author":"Gungorduk","year":"2015","journal-title":"Cancer Res Treat"},{"key":"B10","doi-asserted-by":"publisher","first-page":"99","DOI":"10.5114\/wo.2017.69590","article-title":"Prognostic factors of primary fallopian tube carcinoma","volume":"22","author":"Akkaya","year":"2018","journal-title":"Contemp Oncol (Pozn)"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2013.03.023","article-title":"Primary fallopian tube carcinoma","volume":"169","author":"Kalampokas","year":"2013","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.962613","article-title":"Pure primary ovarian squamous cell carcinoma: a case report and literature review","volume":"12","author":"Luo","year":"2022","journal-title":"Front Oncol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"69","DOI":"10.3760\/cma.j.cn101721-20220925-000437","article-title":"Research progress on the pathogenesis of squamous cell carcinoma","volume":"39","author":"Duan","year":"2023","journal-title":"Clin Med China"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(88)90223-5","article-title":"Pure primary ovarian squamous cell carcinoma","volume":"29","author":"Ben-Baruch","year":"1988","journal-title":"Gynecol Oncol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn112137-20240311-00547","article-title":"Clinical and pathological characteristics of ovary mature cystic teratoma squamous cell carcinoma and primary ovarian squamous cell carcinoma","volume":"104","author":"Zhan","year":"2024","journal-title":"Natl Med J China"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.90715","article-title":"Incidental primary ovarian squamous cell carcinoma arising in endometriosis presenting as adenomyosis-related abnormal uterine bleeding","volume":"17","author":"Mardi","year":"2025","journal-title":"Cureus"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2025.36.e115","article-title":"Cost-effectiveness analysis of reflex p16\/Ki-67 dual-stained cytology in HPV partial genotyping screening in Singapore","volume":"36","author":"Tay","year":"2025","journal-title":"J Gynecol Oncol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.70405","article-title":"Improving detection of CIN2+ and CIN3+ lesions: evaluation of E6\/E7 mRNA, P16, and Ki-67, individually and in combination","volume":"97","author":"Huang","year":"2025","journal-title":"J Med Virol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2008.00878.x","article-title":"Detection of human papilloma virus subtypes 16 and P16(ink4a) in invasive squamous cell carcinoma of the fallopian tube and concomitant squamous cell carcinoma in situ of the cervix","volume":"35","author":"Wang","year":"2009","journal-title":"J Obstet Gynaecol Res"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2017.07.007","article-title":"The HPV E6\/E7 oncogenes: key factors for viral carcinogenesis and therapeutic targets","volume":"26","author":"Hoppe-Seyler","year":"2018","journal-title":"Trends Microbiol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41417-023-00682-3","article-title":"HPV E6\/E7: insights into their regulatory role and mechanism in signaling pathways in HPV-associated tumor","volume":"31","author":"Peng","year":"2024","journal-title":"Cancer Gene Ther"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-200107000-00016","article-title":"A genetic epidemiological study of carcinoma of the fallopian tube","volume":"56","author":"Aziz","year":"2001","journal-title":"Obstetrical Gynecological Survey"},{"key":"B23","article-title":"Primary fallopian tube carcinoma with metastasis in the contralateral ovary","volume":"110","author":"Aich","year":"2012","journal-title":"J Indian Med Assoc"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-024-03636-7","article-title":"Clinicopathological and prognostic factor analyses of primary fallopian tube carcinoma and high-grade serous ovarian cancer: a single-institution retrospective study","volume":"23","author":"Tu","year":"2025","journal-title":"World J Surg Oncol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn112141-20220214-00086","article-title":"Clinical analysis of 23 cases of synchronous primary gynecologic Malignancies","volume":"57","author":"He","year":"2022","journal-title":"Chin J Obstetrics Gynecology"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2017.10.007","article-title":"Synchronous tumours of the female reproductive tract","volume":"50","author":"Gilks","year":"2018","journal-title":"Pathology"},{"key":"B27","article-title":"Synchronous primary cancers of the female reproductive tract in Turkish women","volume":"12","author":"Eser","year":"2011","journal-title":"Asian Pac J Cancer Prev"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13172836","article-title":"Synchronous high-grade squamous intraepithelial lesion of the fimbria of the fallopian tube in a 51-year-old woman with invasive squamous cell carcinoma of the uterine cervix","volume":"13","author":"Wegscheider","year":"2023","journal-title":"Diagnostics (Basel)"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1007\/s13193-011-0081-7","article-title":"Simultaneous squamous cell carcinoma of cervix and fallopian tube: a case report","volume":"2","author":"Kuriakose","year":"2011","journal-title":"Indian J Surg Oncol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-008-0565-z","article-title":"Simultaneous squamous carcinoma involving the fallopian tube and the uterine cervix","volume":"278","author":"Mekni","year":"2008","journal-title":"Arch Gynecol Obstet"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1776043\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:01:51Z","timestamp":1780466511000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1776043\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,3]]},"references-count":30,"alternative-id":["10.3389\/fonc.2026.1776043"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2026.1776043","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,3]]},"article-number":"1776043"}}