{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T07:30:55Z","timestamp":1772177455766,"version":"3.50.1"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>\n                    Myoepithelial tumor (MET) is rare and heterogeneous. We present a case of a MET occurring in the rib and the soft tissue surrounding it. Further, the tumor has been reported to contain both\n                    <jats:italic>EWSR1-PBX3<\/jats:italic>\n                    fusion and rearrangement. A 52-year-old male presented with worsening low back pain. Imaging showed osteolytic destruction of the left twelfth rib accompanied by a soft-tissue mass. Histopathology revealed spindle and oval tumor cells with mild atypia. The entity was positive for S-100, EMA, SMA and calponin by immunohistochemistry but negative for cytokeratin. Testing through next-generation sequencing (NGS) verified the presence of the\n                    <jats:italic>EWSR1-PBX3<\/jats:italic>\n                    fusion and rearrangement. After surgical resection and post-operative radiotherapy, the patient remained disease-free for 2 years. The presence of\n                    <jats:italic>EWSR1-PBX3<\/jats:italic>\n                    fusion and rearrangement in METs of bone and soft tissue is diagnostically significant. It is critical that molecular testing should be performed by clinicians, notably when distinguishing it from synovial sarcoma and other closely related entities.\n                  <\/jats:p>","DOI":"10.3389\/fonc.2026.1776713","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:24:28Z","timestamp":1772169868000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Myoepithelial tumor with EWSR1-PBX3 fusion and rearrangement in rib and soft tissue: a rare case report"],"prefix":"10.3389","volume":"16","author":[{"given":"Junting","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Qingdao University Medical College Affiliated Yantai Yuhuangding Hospital","place":["Yantai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Qingdao University Medical College Affiliated Yantai Yuhuangding Hospital","place":["Yantai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Qingdao University Medical College Affiliated Yantai Yuhuangding Hospital","place":["Yantai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuwei","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Medicine, Xizang Minzu University","place":["Xianyang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boxiukang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Qingdao University Medical College Affiliated Yantai Yuhuangding Hospital","place":["Yantai, 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