{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T04:46:58Z","timestamp":1776919618085,"version":"3.51.2"},"reference-count":114,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Genetic susceptibility is believed to contribute to leukemia development. This study aimed to systematically evaluate the association between DNA repair gene polymorphisms, particularly xeroderma pigmentosum (XP) and excision repair cross-complementing (XRCC) genes, and leukemia risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive search of PubMed, Web of Science, Scopus, and Cochrane Library was conducted until December 3, 2025, concerning the association between DNA repair gene polymorphisms and leukemia risk. Gene expressions were performed in Leukemia DB, GEPIA2, and BloodSpot datasets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty-four studies were included in the meta-analysis. No significant associations were observed for ERCC1 C118T or XPD Asp312Asn across genetic models, whereas ERCC1 8092C&amp;gt;A showed significant associations in homozygous and dominant models. The XPD Lys751Gln polymorphism demonstrated significant associations across all models. Significant associations were identified for XPC Lys939Gln in allelic, homozygous, and recessive models and for XPF Arg415Gln in the heterozygous model. XPG 3507G&amp;gt;C showed no significant association. XRCC1 Arg194Trp, XRCC1 Arg399Gln, and XRCC3 Thr241Met polymorphisms were significantly associated with leukemia risk, while XRCC1 Arg280His was not. Gene expression analyses revealed subtype-specific alterations in DNA repair genes across leukemia datasets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Several DNA repair polymorphisms, including\n                      <jats:italic>XPD Lys751Gln, XPC Lys939Gln, XRCC1 Arg194Trp, XRCC1 Arg399Gln<\/jats:italic>\n                      , and\n                      <jats:italic>XRCC3 Thr241Met<\/jats:italic>\n                      , are associated with increased leukemia susceptibility. Differential expression patterns of DNA repair genes across leukemia subtypes suggest functional heterogeneity and highlight their potential relevance in risk stratification and biomarker development.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1777198","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T04:22:00Z","timestamp":1776918120000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A meta-analysis and expression profiling of DNA repair gene polymorphisms in leukemia"],"prefix":"10.3389","volume":"16","author":[{"given":"Honghui","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Blood Transfusion, Affiliated Jinhua Hospital, Zhejiang University School of Medicine","place":["Jinhua, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinyong","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine","place":["Jinhua, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion, Affiliated Jinhua Hospital, Zhejiang University School of Medicine","place":["Jinhua, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13046-019-1397-3","article-title":"Iron and leukemia: new insights for future treatments","volume":"38","author":"Wang","year":"2019","journal-title":"J Exp Clin Cancer Res"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1586\/14737140.3.3.311","article-title":"The burden and outcomes associated with four leukemias: AML, ALL, CLL and CML","volume":"3","author":"Redaelli","year":"2003","journal-title":"Expert Rev Anticancer Ther"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA: A Cancer J For Clin"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a034819","article-title":"Epidemiology and etiology of leukemia and lymphoma","volume":"10","author":"Bispo","year":"2020","journal-title":"Cold Spring Harbor Perspect Med"},{"key":"B5","article-title":"Appearance of acute myelogenous leukemia (AML) in a patient with breast cancer after adjuvant chemotherapy: Case report and review of the literature","volume":"8","author":"Payandeh","year":"2015","journal-title":"Iran J Cancer Prev"},{"key":"B6","first-page":"49","article-title":"Appearance and disappearance of chronic myeloid leukemia (CML) in patient with chronic lymphocytic leukemia (CLL)","volume":"8","author":"Payandeh","year":"2014","journal-title":"Int J Hematology-Oncology Stem Cell Res"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2015.16.17.7987","article-title":"Survival and clinical aspects for patients with chronic lymphocytic leukemia in Kermanshah, Iran","volume":"16","author":"Payandeh","year":"2015","journal-title":"Asian Pacific J Cancer Prev"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.904292","article-title":"Disease burden, risk factors, and trends of leukemia: a global analysis","volume":"12","author":"Huang","year":"2022","journal-title":"Front Oncol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4125","article-title":"Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia","volume":"22","author":"Li","year":"2016","journal-title":"Nat Med"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12864-017-3617-6","article-title":"Epigenetic and genetic alterations and their influence on gene regulation in chronic lymphocytic leukemia","volume":"18","author":"Huang","year":"2017","journal-title":"BMC Genomics"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2015.16.17.7555","article-title":"Treatment and survival in patients with chronic myeloid leukemia in a chronic phase in West Iran","volume":"16","author":"Payandeh","year":"2015","journal-title":"Asian Pacific J Cancer Prev"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.31557\/apjcc.2019.4.1.1","article-title":"Molecular monitoring of chronic myeloid leukemia in chronic phase (CML-CP)","volume":"4","author":"Payandeh","year":"2019","journal-title":"Asian Pacific J Cancer Care"},{"key":"B13","article-title":"Cholorambucil versus cholorambucil plus prednisolone as first-line therapy of chronic lymphocytic leukemia in west of Iran","volume":"8","author":"Payandeh","year":"2015","journal-title":"Iranian J Cancer Prev"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.7324\/JAPS.2015.50213","article-title":"Non-hematological adverse events of imatinib in patients with chronic myeloid leukemia in chronic phase (CML-CP)","volume":"5","author":"Payandeh","year":"2015","journal-title":"J Appl Pharm Sci"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2020.102951","article-title":"DNA repair pathways as guardians of the genome: Therapeutic potential and possible prognostic role in hematologic neoplasms","volume":"96","author":"Rahimian","year":"2020","journal-title":"DNA Repair"},{"key":"B16","doi-asserted-by":"crossref","DOI":"10.1128\/9781555816704","volume-title":"DNA Repair and Mutagenesis","author":"Friedberg","year":"2005"},{"key":"B17","first-page":"11","article-title":"Molecular mechanisms of DNA repair","volume":"47","author":"Lowran","year":"2021","journal-title":"Michigan Academician"},{"key":"B18","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/S0079-6603(04)79004-2","article-title":"Nucleotide excision repair","volume":"79","author":"Reardon","year":"2005","journal-title":"Prog Nucleic Acid Res Mol Biol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a012583","article-title":"Base excision repair","volume":"5","author":"Krokan","year":"2013","journal-title":"Cold Spring Harbor Perspect Biol"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1101\/gad.349431.122","article-title":"DNA repair defects in cancer and therapeutic opportunities","volume":"36","author":"Hopkins","year":"2022","journal-title":"Genes Dev"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1002\/bip.10239","article-title":"Thermodynamic and structural factors in the removal of bulky DNA adducts by the nucleotide excision repair machinery","volume":"65","author":"Geacintov","year":"2002","journal-title":"Biopolymers: Original Res Biomolecules"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1021\/cr040483f","article-title":"Molecular mechanisms of mammalian global genome nucleotide excision repair","volume":"106","author":"Gillet","year":"2005","journal-title":"Chem Rev"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.11.874","article-title":"Markers of DNA repair and susceptibility to cancer in humans: an epidemiologic review","volume":"92","author":"Berwick","year":"2000","journal-title":"J Natl Cancer Institute"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(00)89088-X","article-title":"Nucleotide excision repair and the link with transcription","volume":"20","author":"Lehmann","year":"1995","journal-title":"Trends Biochem Sci"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/21.4.551","article-title":"XPD polymorphisms: effects on DNA repair proficiency","volume":"21","author":"Lunn","year":"2000","journal-title":"Carcinogenesis"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3390\/ijms16048988","article-title":"Xeroderma pigmentosum: low prevalence of germline XPA mutations in a Brazilian XP population","volume":"16","author":"Santiago","year":"2015","journal-title":"Int J Mol Sci"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3390\/medicina60030478","article-title":"Relationship between XPA, XPB\/ERCC3, XPF\/ERCC4, and XPG\/ERCC5 polymorphisms and the susceptibility to head and neck carcinoma: A systematic review, meta-analysis, and trial sequential analysis","volume":"60","author":"Imani","year":"2024","journal-title":"Med (Kaunas)"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2024.105955","article-title":"Relationship between ERCC1 and XPC polymorphisms and the susceptibility to head and neck carcinoma: A systematic review, meta-analysis, and trial sequential analysis","volume":"162","author":"Imani","year":"2024","journal-title":"Arch Oral Biol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3389\/bjbs.2024.11835","article-title":"Genetic variants associated with response to platinum-based chemotherapy in non-small cell lung cancer patients: A field synopsis and meta-analysis","volume":"81","author":"Sito","year":"2024","journal-title":"Br J BioMed Sci"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.14712\/18059694.2020.27","article-title":"Association of XPC polymorphisms with cutaneous Malignant melanoma risk: Evidence from a meta-analysis","volume":"63","author":"Asadian","year":"2020","journal-title":"Acta Med (Hradec Kralove)"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gki543","article-title":"XRCC1 is required for DNA single-strand break repair in human cells","volume":"33","author":"Brem","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2004.04.012","article-title":"The XRCC genes: expanding roles in DNA double-strand break repair","volume":"3","author":"Thacker","year":"2004","journal-title":"DNA Repair"},{"key":"B33","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1186\/s12967-023-04447-2","article-title":"X-ray cross-complementing family: the bridge linking DNA damage repair and cancer","volume":"21","author":"Liu","year":"2023","journal-title":"J Transl Med"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/S1568-7864(03)00062-4","article-title":"The mammalian XRCC genes: their roles in DNA repair and genetic stability","volume":"2","author":"Thacker","year":"2003","journal-title":"DNA Repair"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2018.00218","article-title":"Associations between XPD Lys751Gln polymorphism and leukemia: a meta-analysis","volume":"9","author":"Wen","year":"2018","journal-title":"Front Genet"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-014-2379-x","article-title":"Association between the XPD\/ERCC2 Lys751Gln polymorphism and risk of cancer: evidence from 224 case-control studies","volume":"35","author":"Wu","year":"2014","journal-title":"Tumor Biol"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2014.01.049","article-title":"The effect of XPD\/ERCC2 Lys751Gln polymorphism on acute leukemia risk: a systematic review and meta-analysis","volume":"538","author":"Liu","year":"2014","journal-title":"Gene"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080687","article-title":"Genetic polymorphisms of XRCC1 and leukemia risk: a meta-analysis of 19 case-control studies","volume":"8","author":"Zhang","year":"2013","journal-title":"PloS One"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-013-1388-5","article-title":"Study on the association between the Arg194Trp polymorphism in the XRCC1 gene and the risk of hematological Malignancies","volume":"35","author":"Tang","year":"2014","journal-title":"Tumor Biol"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-3099-6","article-title":"The Arg399Gln polymorphism in the XRCC1 gene is associated with increased risk of hematological Malignancies","volume":"36","author":"Du","year":"2015","journal-title":"Tumor Biol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12920-021-01076-w","article-title":"Ethnicity-stratified analysis of the association between XRCC3 Thr241Met polymorphism and leukemia: an updated meta-analysis","volume":"14","author":"Xie","year":"2021","journal-title":"BMC Med Genomics"},{"key":"B42","doi-asserted-by":"publisher","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"bmj"},{"key":"B43","first-page":"1","article-title":"The Newcastle-Ottawa scale (NOS) for assessing the quality of nonrandomized studies in meta-analyses","volume":"2","author":"Peterson","year":"2011","journal-title":"Ottawa: Ottawa Hosp Res Institute"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-011890","article-title":"False-positive findings in Cochrane meta-analyses with and without application of trial sequential analysis: an empirical review","volume":"6","author":"Imberger","year":"2016","journal-title":"BMJ Open"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12874-017-0315-7","article-title":"Trial sequential analysis in systematic reviews with meta-analysis","volume":"17","author":"Wetterslev","year":"2017","journal-title":"BMC Med Res Methodol"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.2147\/PGPM.S342625","article-title":"Combined GSTT1 null, GSTM1 null and XPD Lys\/Lys genetic polymorphisms and their association with increased risk of chronic myeloid leukemia","volume":"14","author":"Abdalhabib","year":"2021","journal-title":"Pharmgenomics Pers Med"},{"key":"B47","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1269\/jrr.11093","article-title":"DNA repair polymorphisms in B-cell chronic lymphocytic leukemia in sufferers of Chernobyl Nuclear Power Plant accident","volume":"53","author":"Abramenko","year":"2012","journal-title":"J Radiat Res"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-06-2161","article-title":"Genetic variation in XPD predicts treatment outcome and risk of acute myeloid leukemia following chemotherapy","volume":"104","author":"Allan","year":"2004","journal-title":"Blood"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1179\/1607845412Y.0000000040","article-title":"Association of XRCC1 gene polymorphisms with chronic myeloid leukemia in the population of Andhra Pradesh, India","volume":"18","author":"Annamaneni","year":"2013","journal-title":"Hematology"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2013.05.054","article-title":"XRCC3 Thr241Met polymorphism and risk of acute myeloid leukemia in a Romanian population","volume":"526","author":"B\u0103nescu","year":"2013","journal-title":"Gene"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2013.802781","article-title":"XRCC1 Arg194Trp and Arg399Gln polymorphisms are significantly associated with shorter survival in acute myeloid leukemia","volume":"55","author":"B\u0103nescu","year":"2014","journal-title":"Leukemia Lymphoma"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-016-4815-6","article-title":"Influence of XPC, XPD, XPF, and XPG gene polymorphisms on the risk and the outcome of acute myeloid leukemia in a Romanian population","volume":"37","author":"B\u0103nescu","year":"2016","journal-title":"Tumor Biol"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2008.11.005","article-title":"DNA repair gene XPD and XRCC1 polymorphisms and the risk of childhood acute lymphoblastic leukemia","volume":"33","author":"Batar","year":"2009","journal-title":"Leukemia Res"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2405000","article-title":"DNA repair polymorphisms and outcome of chemotherapy for acute myelogenous leukemia: a report from the Children's Oncology Group","volume":"22","author":"Bhatla","year":"2008","journal-title":"Leukemia"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2011.559672","article-title":"Impact of thymidylate synthase promoter and DNA repair gene polymorphisms on susceptibility to childhood acute lymphoblastic leukemia","volume":"52","author":"Canalle","year":"2011","journal-title":"Leuk Lymphoma"},{"key":"B56","article-title":"Lack of association of XRCC1 codon 399Gln polymorphism with chronic myelogenous leukemia","volume":"27","author":"Deligezer","year":"2007","journal-title":"Anticancer Res"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000133","article-title":"DNA repair gene polymorphisms and their relation with DNA damage, DNA repair, and total antioxidant capacity in childhood acute lymphoblastic leukemia survivors","volume":"37","author":"Dincer","year":"2015","journal-title":"J Pediatr Hematology\/Oncology"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2014.974045","article-title":"Polymorphisms in XPC, XPD and XPG DNA repair genes and leukemia risk in a Tunisian population","volume":"56","author":"Douzi","year":"2015","journal-title":"Leuk Lymphoma"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1089\/gtmb.2011.0152","article-title":"Investigation of Arg399Gln and Arg194Trp polymorphisms of the XRCC1 (x-ray cross-complementing group 1) gene and its correlation to sister chromatid exchange frequency in patients with chronic lymphocytic leukemia","volume":"16","author":"Duman","year":"2012","journal-title":"Genet Test Mol Biomarkers"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1007\/s00580-010-1120-4","article-title":"Detection of XRCC1 gene polymorphisms in Egyptian patients with acute myeloid leukemia","volume":"21","author":"El-Din","year":"2012","journal-title":"Comp Clin Pathol"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-012-1265-4","article-title":"DNA repair polymorphisms influence the risk of second neoplasm after treatment of childhood acute lymphoblastic leukemia","volume":"138","author":"Er\u010dulj","year":"2012","journal-title":"J Cancer Res Clin Oncol"},{"key":"B62","first-page":"1","article-title":"Impact of XRCC genes polymorphisms on leukemic patients","volume":"56","author":"Fekry","year":"2018","journal-title":"Egypt J Pure Appl Sci"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20680","article-title":"DNA repair polymorphisms associated with cytogenetic subgroups in B\u2010cell chronic lymphocytic leukemia","volume":"48","author":"Ganster","year":"2009","journal-title":"Genes Chromosomes Cancer"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2015.02.077","article-title":"The association of folate pathway and DNA repair polymorphisms with susceptibility to childhood acute lymphoblastic leukemia","volume":"562","author":"Gori\u010dar","year":"2015","journal-title":"Gene"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.2310\/JIM.0b013e3182281da3","article-title":"RAD51 and XRCC3 gene polymorphisms and the risk of developing acute myeloid leukemia","volume":"59","author":"Hamdy","year":"2011","journal-title":"J Invest Med"},{"key":"B66","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.canlet.2004.06.055","article-title":"DNA repair gene XRCC1 polymorphisms in childhood acute lymphoblastic leukemia","volume":"217","author":"Joseph","year":"2005","journal-title":"Cancer Lett"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.4103\/jnsbm.JNSBM_194_17","article-title":"Impact of polymorphisms of TP53 Arg72Pro, excision repair cross-complementing Protein 1 Asn118Asn (C118T) and deletion in Intron 2 of BIM in chronic myeloid leukemia patients on imatinib treatment","volume":"9","author":"Kagita","year":"2018","journal-title":"J Natural Science Biol Med"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2011.625576","article-title":"Association of GSTT1 polymorphism with acute myeloid leukemia risk is dependent on smoking status","volume":"53","author":"Kim","year":"2012","journal-title":"Leukemia Lymphoma"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.3339","article-title":"Association of DNA repair gene XPC Ala499Val (rs2228000 C>T) and Lys939Gln (rs2228001 A>C) polymorphisms with the risk of chronic myeloid leukemia: A case-control study in a South Indian population","volume":"23","author":"Lakkireddy","year":"2021","journal-title":"J Gene Med"},{"key":"B70","volume-title":"Association of the XRCC1 polymorphism with leukemia susceptibility in northwest Chinese population.","author":"Li","year":"2011"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2011.01.014","article-title":"RAD51 and XRCC3 polymorphisms: Impact on the risk and treatment outcomes of de novo inv (16) or t (16, 16)\/CBF\u03b2\u2013MYH11 (+) acute myeloid leukemia","volume":"35","author":"Liu","year":"2011","journal-title":"Leukemia Res"},{"key":"B72","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1093\/carcin\/bgi280","article-title":"DNA repair polymorphisms and cancer risk in non-smokers in a cohort study","volume":"27","author":"Matullo","year":"2006","journal-title":"Carcinogenesis"},{"key":"B73","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1182\/blood-2005-06-2305","article-title":"XPD Lys751Gln polymorphism in the etiology and outcome of childhood acute myeloid leukemia: a Children's Oncology Group report","volume":"107","author":"Mehta","year":"2006","journal-title":"Blood"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.4238\/vol8-4gmr687","article-title":"XRCC1 polymorphisms and haplotypes in Mexican patients with acute lymphoblastic leukemia","volume":"8","author":"Meza-Espinoza","year":"2009","journal-title":"Genet Mol Res"},{"key":"B75","article-title":"Relationship between RAD51-G135C and XRCC3-C241T single nucleotide polymorphisms and onset of acute myeloid leukemia","volume":"23","author":"Miao","year":"2015","journal-title":"Zhongguo shi yan xue ye xue za zhi"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.4103\/ejh.ejh_22_19","article-title":"X-ray cross-complement 1 gene polymorphisms (Arg399Gln and Arg194Trp) in patients with acute myeloid leukemia","volume":"44","author":"Mortada","year":"2019","journal-title":"Egyptian J Hematol"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1007\/s12288-014-0482-1","article-title":"Identification of XRCC1 Arg399Gln and XRCC3 Thr241Met polymorphisms in a Turkish population and their association with the risk of chronic lymphocytic leukemia","volume":"31","author":"Mutlu","year":"2015","journal-title":"Indian J Hematol Blood Transfusion"},{"key":"B78","doi-asserted-by":"publisher","first-page":"8860","DOI":"10.5897\/AJB10.1839","article-title":"Polymorphisms of the DNA repair gene XPD (751) and XRCC1 (399) correlates with risk of hematological Malignancies in Turkish population","volume":"10","author":"\u00d6zcan","year":"2011","journal-title":"Afr J Biotechnol"},{"key":"B79","article-title":"DNA repair genes and chronic myeloid leukemia: ERCC2 (751), XRCC1 (399), XRCC4-Intron 3, XRCC4 (-1394) gene polymorphisms","volume":"13","author":"Ozdilli","year":"2021","journal-title":"Mediterr J Hematol Infect Dis"},{"key":"B80","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1002\/pbc.20742","article-title":"Genetic polymorphisms and haplotypes of DNA repair genes in childhood acute lymphoblastic leukemia","volume":"48","author":"Pakakasama","year":"2007","journal-title":"Pediatr Blood Cancer"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S178411","article-title":"The contribution of XRCC3 genotypes to childhood acute lymphoblastic leukemia","volume":"10","author":"Pei","year":"2018","journal-title":"Cancer Manage Res"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-3874-4","article-title":"Concurrent effects of ABCB1 C3435T, ABCG2 C421A, and XRCC1 Arg194Trp genetic polymorphisms with risk of cancer, clinical output, and response to treatment with imatinib mesylate in patients with chronic myeloid leukemia","volume":"37","author":"Salimizand","year":"2016","journal-title":"Tumor Biol"},{"key":"B83","article-title":"Risk effects of XRCC1 Arg399Gln and XPD Lys751Gln gene polymorphisms in de novo acute myeloid leukemia-a study from India","volume":"16","author":"Santhi","year":"2017","journal-title":"Indian J Biotechnol"},{"key":"B84","article-title":"The genotype distribution of the XRCC1 gene indicates a role for base excision repair in the development of therapy-related acute myeloblastic leukemia","volume":"100","author":"Seedhouse","year":"2002","journal-title":"Blood J Am Soc Hematol"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-03-0372","article-title":"Polymorphisms in genes involved in homologous recombination repair interact to increase the risk of developing acute myeloid leukemia","volume":"10","author":"Seedhouse","year":"2004","journal-title":"Clin Cancer Res"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25318","article-title":"Genetic variations of DNA repair genes and their prognostic significance in patients with acute myeloid leukemia","volume":"128","author":"Shi","year":"2011","journal-title":"Int J Cancer"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2014.08.002","article-title":"NBN and XRCC3 genetic variants in childhood acute lymphoblastic leukemia","volume":"38","author":"Smolkova","year":"2014","journal-title":"Cancer Epidemiol"},{"key":"B88","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1089\/gtmb.2012.0278","article-title":"The genotype distribution of the XRCC1, XRCC3, and XPD DNA repair genes and their role for the development of acute myeloblastic leukemia","volume":"17","author":"Sorour","year":"2013","journal-title":"Genet Test Mol Biomarkers"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-010-0127-x","article-title":"The association of polymorphisms in DNA base excision repair genes XRCC1, OGG1 and MUTYH with the risk of childhood acute lymphoblastic leukemia","volume":"38","author":"Stanczyk","year":"2011","journal-title":"Mol Biol Rep"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2010.02.035","article-title":"DNA repair XRCC1 Arg399Gln polymorphism alone, and in combination with CYP2E1 polymorphisms significantly contribute to the risk of development of childhood acute lymphoblastic leukemia","volume":"34","author":"Tumer","year":"2010","journal-title":"Leukemia Res"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2006.03.027","article-title":"Polymorphisms in ERCC1 and susceptibility to childhood acute lymphoblastic leukemia in a Chinese population","volume":"30","author":"Wang","year":"2006","journal-title":"Leuk Res"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1016\/S1007-4376(09)60034-4","article-title":"Polymorphisms in XRCC5, XRCC6, XRCC7 genes are involved in DNA double-strand breaks (DSBs) repair associated with the risk of acute myeloid leukemia (AML) in Chinese population","volume":"23","author":"Wang","year":"2009","journal-title":"J Nanjing Med Univ"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.4103\/ejh.ejh_59_23","article-title":"Impact of XRCC3 rs861539 and XPD rs13181 gene polymorphisms on childhood acute lymphoblastic leukemia in Egyptian patients","volume":"48","author":"Wilson","year":"2023","journal-title":"Egyptian J Hematol"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.5455\/jeim.301114.or.115","article-title":"DNA repair gene XRCC1 and XRCC3 polymorphisms and their association with chronic myelogenous leukemia","volume":"4","author":"Yalcin","year":"2014","journal-title":"Journal of Experimental and Integrative Medicine"},{"key":"B95","first-page":"299","article-title":"Relationship between RAD51-G135C\/XRCC3-C241T polymorphisms and development of acute myeloid leukemia with recurrent chromosome translocation","volume":"32","author":"Yang","year":"2011","journal-title":"Zhonghua xue ye xue za zhi= Zhonghua Xueyexue Zazhi"},{"key":"B96","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/s13104-022-05918-3","article-title":"Association of DNA repair genes polymorphisms with childhood acute lymphoblastic leukemia: a high-resolution melting analysis","volume":"15","author":"Zehtab","year":"2022","journal-title":"BMC Res Notes"},{"key":"B97","article-title":"Relationship between NQO1C (609T), RAD51 (G135C), XRCC3 (C241T) single nucleotide polymorphisms and acute lymphoblastic leukemia","volume":"17","author":"Zhang","year":"2009","journal-title":"Zhongguo shi yan xue ye xue za zhi"},{"key":"B98","article-title":"Association of genetic polymorphism of XRCC1 with susceptibility to acute childhood leukemia","volume":"34","author":"Zhu","year":"2005","journal-title":"Wei Sheng yan jiu= J Hygiene Res"},{"key":"B99","article-title":"Polymorphisms and haplotypes of XRCC1 and APE1 and risk of childhood leukemia in China: A case-control analysis","volume":"13","author":"Zhu","year":"2008","journal-title":"Eur J Oncol"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S340283","article-title":"Age-and gender-independent association of XRCC1 Arg399Gln polymorphism with chronic myeloid leukemia","volume":"14","author":"Abdalhabib","year":"2021","journal-title":"Int J Gen Med"},{"key":"B101","article-title":"Polymorphisms in DNA repair genes and associations with cancer risk","volume":"11","author":"Goode","year":"2002","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1007\/s10930-007-9095-y","article-title":"Conformational effects of a common codon 399 polymorphism on the BRCT1 domain of the XRCC1 protein","volume":"26","author":"Monaco","year":"2007","journal-title":"Protein J"},{"key":"B103","article-title":"Modulation of nucleotide excision repair capacity by XPD polymorphisms in lung cancer patients","volume":"61","author":"Spitz","year":"2001","journal-title":"Cancer Res"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1002\/em.20569","article-title":"Mammalian nucleotide excision repair proteins and interstrand crosslink repair","volume":"51","author":"Wood","year":"2010","journal-title":"Environ Mol Mutagen"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2014.03.014","article-title":"Mouse SLX4 is a tumor suppressor that stimulates the activity of the nuclease XPF-ERCC1 in DNA crosslink repair","volume":"54","author":"Hodskinson","year":"2014","journal-title":"Mol Cell"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.6.2415","article-title":"Reconstitution of human DNA repair excision nuclease in a highly defined system (\u2217)","volume":"270","author":"Mu","year":"1995","journal-title":"J Biol Chem"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201695223","article-title":"Recruitment and positioning determine the specific role of the XPF\u2010ERCC 1 endonuclease in interstrand crosslink repair","volume":"36","author":"Klein Douwel","year":"2017","journal-title":"EMBO J"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1008555","article-title":"XPF-ERCC1 protects liver, kidney and blood homeostasis outside the canonical excision repair pathways","volume":"16","author":"Mulderrig","year":"2020","journal-title":"PloS Genet"},{"key":"B109","doi-asserted-by":"publisher","first-page":"47","DOI":"10.2147\/PGPM.S20317","article-title":"ERCC1 and XRCC1 as biomarkers for lung and head and neck cancer","volume":"4","author":"Vaezi","year":"2011","journal-title":"Pharmacogenomics Pers Med"},{"key":"B110","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.mrfmmm.2011.01.001","article-title":"XRCC1 and ERCC1 variants modify Malignant mesothelioma risk: A case\u2013control study","volume":"708","author":"Betti","year":"2011","journal-title":"Mutat Res Fundam Mol Mech Mutagen"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/geu088","article-title":"XRCC1 and ERCC1 polymorphisms are related to susceptibility and survival of colorectal cancer in the Chinese population","volume":"30","author":"Dai","year":"2015","journal-title":"Mutagenesis"},{"key":"B112","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.canlet.2004.11.016","article-title":"Combinations of polymorphisms in XPD, XPC and XPA in relation to risk of lung cancer","volume":"222","author":"Vogel","year":"2005","journal-title":"Cancer Lett"},{"key":"B113","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s12308-017-0290-2","article-title":"Polymorphisms of xeroderma pigmentosum genes (XPC, XPD, and XPG) and susceptibility to acute leukemia among a sample of Egyptian patients","volume":"10","author":"ElMahgoub","year":"2017","journal-title":"J Hematopathol"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-02-0395","article-title":"Racial and ethnic differences in survival of children with acute lymphoblastic leukemia","volume":"100","author":"Bhatia","year":"2002","journal-title":"Blood J Am Soc Hematol"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1777198\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T04:22:04Z","timestamp":1776918124000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1777198\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,23]]},"references-count":114,"alternative-id":["10.3389\/fonc.2026.1777198"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2026.1777198","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,23]]},"article-number":"1777198"}}