{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T02:07:14Z","timestamp":1773194834541,"version":"3.50.1"},"reference-count":18,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>This case report describes the innovative integration of Cone-beam CT (CBCT) \u2013 derived parenchymal blood volume (PBV) mapping with embolization guidance technology to successfully direct the combined treatment of transarterial chemoembolization (TACE) and cryoablation of in a 70-year-old female with recurrent, hypovascular gallbladder liver metastases. By utilizing PBV software to quantitatively analyze tumor perfusion patterns through cone-beam CT acquisitions, the interventional team overcame the diagnostic limitations of conventional angiography in visualizing these typically occult lesions, identifying a characteristic peripheral hyperperfusion signature. Subsequently, the embolization guidance software automatically detected the tumor-feeding arteries and projected this information onto real-time fluoroscopy, enabling precise superselective catheterization. Post-TACE lipiodol deposition served as a radiopaque marker for accurate cryoablation probe placement under CT guidance. The procedural endpoint was objectively confirmed by a quantifiable change in PBV values, transitioning from pre-operative hypoperfusion to a post-operative \u201cblack cavity\u201d pattern, indicative of complete treatment response. This novel multi-modal image-guided approach establishes a new paradigm for managing complex hepatic metastases, providing a comprehensive single-session solution for lesion identification, targeted embolization, and verified ablation.<\/jats:p>","DOI":"10.3389\/fonc.2026.1778300","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T05:29:09Z","timestamp":1773120549000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Cone-beam CT-derived parenchymal blood volume imaging in transarterial chemoembolization for hypovascular hepatic metastases: a case report"],"prefix":"10.3389","volume":"16","author":[{"given":"Hao","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Interventional Radiology, Tianjin First Center Hospital","place":["Tianjin, China"]},{"name":"Tianjin Institute of Imaging Medicine","place":["Tianjin, China"]},{"name":"Tianjin Organ Transplant 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China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xunjin","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, Tianjin First Center Hospital","place":["Tianjin, China"]},{"name":"Tianjin Institute of Imaging Medicine","place":["Tianjin, China"]},{"name":"Tianjin Organ Transplant Research Center","place":["Tianjin, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, Tianjin First Center Hospital","place":["Tianjin, China"]},{"name":"Tianjin Institute of Imaging Medicine","place":["Tianjin, China"]},{"name":"Tianjin Organ Transplant Research Center","place":["Tianjin, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haonan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, Tianjin First Center 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