{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T05:41:51Z","timestamp":1776231711041,"version":"3.50.1"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the associations between C allele of CYP1A1 rs4646903 (T&amp;gt;C) and G allele of CYP1A1 rs1048943 (A&amp;gt;G) polymorphisms and prostate cancer (PCa) susceptibility under different genetic models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We systematically searched PubMed, EMBASE, CNKI, and Wanfang databases from inception to December 31, 2024. Eligible case\u2013control studies were selected. Study quality was assessed using the Newcastle\u2013Ottawa Scale (NOS). Meta-analyses were performed using RevMan 5.3 software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifteen studies for rs4646903 and 14 studies for rs1048943 were included. For rs4646903 (T&amp;gt;C): The dominant model (CC+CT vs TT) showed that carrying the C allele was associated with increased PCa risk (OR\u00a0=\u00a01.39, 95%CI: 1.13\u20131.71, P\u00a0=\u00a00.002). For rs1048943 (A&amp;gt;G): Carrying the G allele was associated with decreased PCa risk in multiple models: allele model (G vs A: OR\u00a0=\u00a00.80, 95%CI: 0.71\u20130.90, P&amp;lt;0.001); homozygous model (GG vs AA: OR\u00a0=\u00a00.56, 95%CI: 0.42\u20130.76, P&amp;lt;0.001); dominant model (GA+GG vs AA: OR\u00a0=\u00a00.72, 95%CI: 0.55\u20130.94, P\u00a0=\u00a00.02); recessive model (GG vs GA+AA: OR\u00a0=\u00a00.78, 95%CI: 0.62\u20130.99, P\u00a0=\u00a00.04).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The C allele of CYP1A1 rs4646903 may increase PCa risk under the dominant model. The G allele of CYP1A1 rs1048943 may reduce PCa risk across multiple genetic models.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1779274","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T04:41:57Z","timestamp":1776228117000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between CYP1A1 gene polymorphisms at rs4646903 and rs1048943 loci and susceptibility to prostate cancer: meta-analysis"],"prefix":"10.3389","volume":"16","author":[{"given":"Ruobing","family":"Teng","sequence":"first","affiliation":[{"name":"Department of Urology, The Second Affiliated Hospital of Guilin Medical University","place":["Guilin, Guangxi, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital of Guilin Medical University","place":["Guilin, Guangxi, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengqian","family":"Teng","sequence":"additional","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital of Guilin Medical University","place":["Guilin, Guangxi, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujiang","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital of Guilin Medical University","place":["Guilin, Guangxi, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.2002.02823.x","article-title":"Patterns and trends in prostate cancer incidence, survival, prevalence, and mortality. 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