{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T04:59:19Z","timestamp":1781240359083,"version":"3.54.1"},"reference-count":53,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To systematically evaluate the efficacy and safety of radical antegrade modular pancreatosplenectomy (RAMPS) versus conventional distal pancreatectomy (CDP) for left-sided pancreatic cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Computerized searches were conducted in PubMed, Embase, Cochrane Library, CNKI, Wanfang Data and other Chinese and English databases to collect studies comparing RAMPS with CDP for left-sided pancreatic cancer published from January 2003 to October 2025. Two researchers independently completed literature screening and data extraction; the ROBINS-I tool was used for bias risk assessment; RevMan 5.4.1 software was used for effect size combination, and R software was used for sensitivity analysis and publication bias analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>A total of 21 studies were included, involving 2,591 patients, among which 9 were propensity score-matched (PSM) studies. The results of the meta-analysis showed that compared with CDP, RAMPS could significantly increase the R0 resection rate (RR = 1.10, 95% CI: 1.03-1.18, P = 0.007) and the number of lymph nodes dissected (MD = 3.58, 95%CI 1.66 \u2013 5.50, P&amp;lt;0.001). However, substantial heterogeneity was noted for these outcomes (I2\u00a0=\u00a072%\/93%). No significant differences were found in operative time, blood loss, hospital stay, overall complication rates, or perioperative mortality. Crucially, there were no significant differences in overall survival (HR = 0.93, 95% CI: 0.76-1.13, P = 0.46) or disease-free survival (HR = 1.01, 95% CI: 0.77-1.33, P = 0.92) between the two procedures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>For left-sided pancreatic cancer, RAMPS may offer advantages in local tumor control and surgical radicality; however, such advantages have not been shown to translate into meaningful improvements in survival outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1782903","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T04:46:20Z","timestamp":1781239580000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy comparison of radical antegrade modular pancreatosplenectomy versus conventional distal pancreatectomy in the treatment of left-sided pancreatic cancer: a meta-analysis and systematic review"],"prefix":"10.3389","volume":"16","author":[{"given":"Jincheng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, The Third Hospital of Mianyang, Sichuan Mental Health Center","place":["Mianyang, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangqiang","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, The Third Hospital of Mianyang, Sichuan Mental Health Center","place":["Mianyang, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, Meishan City People\u2019s Hospital","place":["Meishan, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Furui","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Zigong Fourth People\u2019s Hospital","place":["Zigong, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17101607","article-title":"Unraveling the burden of pancreatic cancer in the 21st century: Trends in incidence, mortality, survival, and key contributing factors","volume":"17","author":"Zottl","year":"2025","journal-title":"Cancers (Basel)"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16101808","article-title":"Driver mutations in pancreatic cancer and opportunities for targeted therapy","volume":"16","author":"Olaoba","year":"2024","journal-title":"Cancers 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