{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T04:46:03Z","timestamp":1788497163464,"version":"build-2803163510"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>\n                    Calcified chondroid mesenchymal neoplasm (CCMN) is a recently characterized solid tumor of bone and soft tissue. Its histological features include the formation of cartilage or chondroid matrix, while molecular characteristics are marked by the presence of\n                    <jats:italic>FN1<\/jats:italic>\n                    gene rearrangement. This article presents a rare case of CCMN occurring in the perineum of a 59-year-old female. The tumor exhibits the following characteristics: grossly, it appears as a solid nodule; histologically, it demonstrates lobulated growth, with polygonal, oval, or spindle-shaped cells observed within the chondroid matrix, alongside a significant number of osteoclast-like giant cells and calcium phosphate-like deposits. Molecular testing confirmed the presence of an\n                    <jats:italic>FN1<\/jats:italic>\n                    (exon 36):\n                    <jats:italic>:FGFR2<\/jats:italic>\n                    (exon 2) gene fusion through RNA sequencing. Immunohistochemical staining did not provide substantial assistance in diagnosing CCMN. Although recurrence occurred post-surgical resection, it was not common. Currently, there are no reported cases of metastasis. Existing literature primarily identifies such tumors in the distal extremities and temporomandibular joint; however, the case reported herein is the first documented occurrence in the perineum of a female. This finding suggests that the spectrum of CCMN may extend beyond the traditionally recognized locations of the distal extremities and temporomandibular joint.\n                  <\/jats:p>","DOI":"10.3389\/fonc.2026.1783265","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T06:49:45Z","timestamp":1773384585000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Calcified chondroid mesenchymal neoplasm: a case report of perineal involvement and literature review"],"prefix":"10.3389","volume":"16","author":[{"given":"Chenxi","family":"Weng","sequence":"first","affiliation":[{"name":"Department of Nursing, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University","place":["Yiwu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanli","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University","place":["Yiwu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqian","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University","place":["Yiwu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gangping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang 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