{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:27:23Z","timestamp":1788877643277,"version":"build-2803163510"},"reference-count":18,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>\n                    This article reports a rare case of chronic myeloid leukemia (CML) in blast phase presenting clinically as T-lymphoblastic lymphoma (T-LBL). A 56-year-old male was admitted due to cervical masses, and lymph node biopsy initially diagnosed T-LBL. Subsequent bone marrow examination revealed positivity for the BCR::ABL1 (P210) fusion gene. Flow cytometry (FCM) and immunohistochemistry (IHC) confirmed that the tumor cells co-expressed T-lymphoid and myeloid antigens, and fluorescence\n                    <jats:italic>in situ<\/jats:italic>\n                    hybridization (FISH) detected BCR::ABL1 fusion signals in lymph node tissue, leading to the final diagnosis of\n                    <jats:italic>de novo<\/jats:italic>\n                    blast phase CML (BP-CML) with mixed phenotype (T-lineage and myeloid expression). The chromosomal karyotype evolved from the initial complex karyotype t(22;22) to t(9;22;22), revealing that the Philadelphia (Ph) chromosome translocation was the initiating event of the disease. The patient achieved molecular remission following chemotherapy with the Hyper-CVAD\/MA regimen combined with a tyrosine kinase inhibitor (TKI). This case underscores the importance of differentiating BP-CML among adult Ph-positive T-lymphoblastic neoplasms and highlights the value of multi-platform integrated diagnosis for identifying atypical presentations.\n                  <\/jats:p>","DOI":"10.3389\/fonc.2026.1784891","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T04:47:06Z","timestamp":1776055626000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Chronic myeloid leukemia in blast phase masquerading as T-lymphoblastic lymphoma with t(22;22) karyotype: a case report"],"prefix":"10.3389","volume":"16","author":[{"given":"Yang","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Hematology, Lanzhou University Second Hospital, Lanzhou University","place":["Lanzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengdong","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Hematology, Lanzhou University Second Hospital, Lanzhou University","place":["Lanzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Bai","sequence":"additional","affiliation":[{"name":"Key Laboratory of the Hematology of Gansu Province, Lanzhou University Second Hospital, Lanzhou University","place":["Lanzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hematology, Lanzhou University Second Hospital, Lanzhou University","place":["Lanzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Lanzhou University Second Hospital, Lanzhou University","place":["Lanzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Hematology, Lanzhou University Second Hospital, Lanzhou University","place":["Lanzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liansheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Lanzhou University Second Hospital, Lanzhou University","place":["Lanzhou, China"]},{"name":"Key Laboratory of the Hematology of Gansu Province, Lanzhou University Second Hospital, Lanzhou University","place":["Lanzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology, Lanzhou University Second Hospital, Lanzhou University","place":["Lanzhou, China"]},{"name":"Key Laboratory of the Hematology of Gansu Province, Lanzhou 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