{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T08:13:17Z","timestamp":1773389597261,"version":"3.50.1"},"reference-count":19,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>The etiology of fever of unknown origin (FUO) is complex and diverse, with benign neoplasms remaining a rarely reported cause. This case report describes a young female patient who presented with FUO and persistently elevated inflammatory markers. A comprehensive diagnostic workup revealed no clear evidence of infectious, autoimmune, or malignant disease. However, during hospitalization, a previously stable, painless mass on her left foot, which presented for two years, exhibited increased local skin temperature. Imaging studies identified a metabolically active subcutaneous lesion at the site. The patient\u2019s condition improved rapidly following excision of the mass, and histopathological examination confirmed the diagnosis of soft tissue myoepithelioma. Soft tissue myoepithelioma, a rare neoplasm of uncertain differentiation, was identified as the underlying etiology of the patient\u2019s clinical presentation. Typically characterized by an indolent and subtle clinical course, this neoplasm most commonly manifests as a painless mass in the extremities or trunk. The disease exhibits a roughly equal sex distribution, with a peak incidence occurring between the ages of 30 and 40 years. Histologically, soft tissue myoepithelioma demonstrates a heterogeneous composition of myoepithelial cell types, predominantly epithelioid cells, and exhibits immunohistochemical expression of both epithelial and myogenic lineage markers. It is noteworthy that fever associated with myoepithelioma is extremely rare, with very few cases reported in the literature to date. This case highlights the rare presentation of soft tissue myoepithelioma as a hyperinflammatory fever, thereby expanding the recognized clinical spectrum of this tumor and deepening the understanding of this distinct entity.<\/jats:p>","DOI":"10.3389\/fonc.2026.1784983","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T05:25:36Z","timestamp":1773379536000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Benign myoepithelioma presenting as fever of unknown origin: a rare clinical manifestation of an uncommon tumor"],"prefix":"10.3389","volume":"16","author":[{"given":"Yiran","family":"Shou","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Peking Union Medical College Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Congwei","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Pathology, Peking Union Medical College Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaotong","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Peking Union Medical College Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Peking Union Medical College Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taisheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Peking Union Medical College Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Peking Union Medical College Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengyin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Peking Union Medical College Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofac396","article-title":"Geographic influence upon noninfectious diseases accounting for fever of unknown origin: A systematic review and meta-analysis","volume":"9","author":"Wright","year":"2022","journal-title":"Open Forum Infect Dis"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200309000-00001","article-title":"Myoepithelial tumors of soft tissue: A clinicopathologic and immunohistochemical study of 101 cases with evaluation of prognostic parameters","volume":"27","author":"Hornick","year":"2003","journal-title":"Am J Surg Pathol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2019.05.003","article-title":"Myoepithelioma of the soft tissue: A systematic review of clinical reports","volume":"45","author":"Rastrelli","year":"2019","journal-title":"Eur J Surg Oncol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2008.124","article-title":"Heterogeneous genetic profiles in soft tissue myoepitheliomas","volume":"21","author":"Hallor","year":"2008","journal-title":"Modern Pathol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1177\/1938640012470713","article-title":"Cutaneous myoepithelioma in the foot: case report","volume":"6","author":"Dix","year":"2013","journal-title":"Foot Ankle Specialist"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31805f6775","article-title":"Myoepithelial carcinoma of soft tissue in children: an aggressive neoplasm analyzed in a series of 29 cases","volume":"31","author":"Gleason","year":"2007","journal-title":"Am J Surg Pathol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1186\/1757-1626-3-25","article-title":"Benign myoepithelioma of the lung - 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