{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T04:59:50Z","timestamp":1785387590289,"version":"3.55.0"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ganglioneuroblastoma (GNB) is a malignant neoplasm of the autonomic nervous system on the spectrum of peripheral neuroblastic tumors (PNT), exceedingly rare in adults with only a limited number of cases documented in literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>We present the case of a 57-year-old male who was found to have a large nodular lesion in the left adrenal gland, which was later confirmed as a ganglioneuroblastoma following adrenalectomy, with multiple skeletal metastases and, most notably, a large, growing and destructive metastasis in the right frontoparietal region of the skull with extradural extension and invasion of the superior sagittal sinus. We discuss the patient\u2019s clinical, radiological, and pathological findings in correlation with the current literature and recommendations regarding this type of tumor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case, associated with a review of the literature, highlights the malignant potential of ganglioneuroblastoma in adults and emphasizes the need for early diagnosis, a multidisciplinary treatment approach, and further investigation into optimal management strategies for this rare entity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1787041","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T04:21:39Z","timestamp":1785385299000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Adult adrenal ganglioneuroblastoma with an extensive metastasis of the skull: case report and review of the literature"],"prefix":"10.3389","volume":"16","author":[{"given":"Willem","family":"Vandenhoudt","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, University Hospitals Leuven","place":["Leuven, Belgium"]},{"name":"Department of Neurosurgery, ZAS Hospitals Antwerp","place":["Antwerp, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Van Havenbergh","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, ZAS Hospitals Antwerp","place":["Antwerp, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Van Havenbergh","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, ZAS Hospitals Antwerp","place":["Antwerp, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-017-9484-5","article-title":"Update on adrenal tumours in 2017 world health organization (WHO) of endocrine tumours","volume":"28","author":"King-yin Lam","year":"2017","journal-title":"Endocr Pathol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1148\/radiographics.22.4.g02jl15911","article-title":"Neuroblastoma, ganglioneuroblastoma and ganglioneuroma: radiologic-pathologic correlation","volume":"22","author":"Lonergan","year":"2002","journal-title":"Radiographics"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.869518","article-title":"Neuroblastic tumors of the adrenal gland in elderly patients: a case report and review of the literature","volume":"10","author":"Deslarzes","year":"2022","journal-title":"Front Pediatr"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199905000-00005","article-title":"Metastatic sites in stage IV and IVS neuroblastoma correlate with age, tumor biology, and survival","volume":"21","author":"DuBois","year":"1999","journal-title":"J Pediatr Hematol Oncol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20859","article-title":"Neuroblastoma in adults: incidence and survival analysis based on SEER data","volume":"49","author":"Esiashvili","year":"2007","journal-title":"Pediat Blood Cancer"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1186\/2162-3619-3-20","article-title":"Neuroblastoma of the elderly, an oncologist's nightmare: case presentation, literature review and SEER database analysis","volume":"3","author":"Rogowitz","year":"2014","journal-title":"Exp Hematol Oncol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-008-4084-0","article-title":"Adult-onset adrenal ganglioneuroblastoma - 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