{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T11:05:08Z","timestamp":1783595108363,"version":"3.55.0"},"reference-count":15,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Epithelioid mesothelioma with a clear cell morphology is rare and has only been described in a few case reports. The diagnosis of epithelioid clear cell mesothelioma is challenging and often requires extensive immunohistochemical staining. Here, we report a case of epithelioid mesothelioma, clear cell variant, occurring in the peritoneum of a 76-year-old male. Computed Tomography(CT)imaging revealed a localized irregular intra-abdominal mass measuring approximately 6.0\u00d75.0cm. Combined with histomorphology and immunophenotype analysis, the patient was diagnosed with localized epithelioid clear cell mesothelioma. There was no recurrence or metastasis after 24 months of follow-up. This case enriches the clinical and molecular data of localized peritoneal epithelioid clear cell mesothelioma, and provides insights into its diagnosis, differential diagnosis, and treatment.<\/jats:p>","DOI":"10.3389\/fonc.2026.1790964","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T04:26:12Z","timestamp":1778732772000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Localized peritoneal epithelioid clear cell subtype mesothelioma: a case report and literature review"],"prefix":"10.3389","volume":"16","author":[{"given":"Bin","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Pathology, The First People\u2019s Hospital of Xiaoshan District","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongsheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology, The First People\u2019s Hospital of Xiaoshan District","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of General Practice, Chengxiang Sub-district Community Health Service Center of Xiaoshan District","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3389\/pore.2023.1611577","article-title":"Clinical and pathological observation of conversion therapy for Malignant peritoneal mesothelioma: a case report and literature review","volume":"29","author":"Deng","year":"2024","journal-title":"Pathol Oncol Res"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2005.02.014","article-title":"Mesothelioma with clear cell features: an ultrastructural and immunohistochemical study of 20 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