{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T09:11:35Z","timestamp":1774257095041,"version":"3.50.1"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>RDM1 is linked to poor prognosis in hepatocellular carcinoma (HCC) chemotherapy. We investigated its post-transcriptional regulation and developed a targeted co-delivery strategy to enhance chemosensitivity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Clinical data were analyzed for RDM1 prognostic value. Post-transcriptional regulation by 5-azacytidine (5-Aza) and synergy with doxorubicin (ADM) were assessed via DNA damage repair and apoptosis assays. A transferrin-modified liposome (AA@Tf-Lip) was constructed for co-delivery, and antitumor efficacy evaluated\n                      <jats:italic>in vitro<\/jats:italic>\n                      and\n                      <jats:italic>in vivo<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>High RDM1 expression predicted poor HCC survival. 5-Aza downregulated RDM1 by reducing mRNA stability, inhibiting RAD51-mediated homologous recombination repair, and synergistically activating p53\/Bax apoptosis with ADM. AA@Tf-Lip enhanced cellular uptake and tumor specificity, achieving higher tumor inhibition and reduced cardiotoxicity versus free drugs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Indirect RDM1 inhibition via post-transcriptional regulation combined with targeted co-delivery effectively enhances HCC chemosensitivity, offering a safe, precise therapeutic strategy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1792167","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T08:33:22Z","timestamp":1774254802000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Transferrin-modified liposomes enhance chemosensitivity in hepatocellular carcinoma by suppressing RDM1-mediated DNA repair"],"prefix":"10.3389","volume":"16","author":[{"given":"Xiaoni","family":"Cai","sequence":"first","affiliation":[{"name":"Department of General Surgery, Shangyu People\u2019s Hospital of Shaoxing","place":["Shaoxing, Zhejiang, China"]},{"name":"School of Medicine, Shaoxing University","place":["Shaoxing, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Shandong Provincial Third Hospital, Shandong University","place":["Jinan, Shandong, China"]},{"name":"Shandong Provincial Third Hospital Medical Research Center, Hepatobiliary Minimally Invasive Research Lab","place":["Jinan, Shandong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiongdan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of The First Clinical Medical School, Hainan Medical University","place":["Haikou, Hainan, China"]},{"name":"Hainan Academy of Medicine Sciences","place":["Haikou, Hainan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Shangyu People\u2019s Hospital of Shaoxing","place":["Shaoxing, Zhejiang, China"]},{"name":"School of Medicine, Shaoxing University","place":["Shaoxing, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Shangyu People\u2019s Hospital of Shaoxing","place":["Shaoxing, Zhejiang, China"]},{"name":"School of Medicine, Shaoxing University","place":["Shaoxing, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenqiao","family":"Lyu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Shangyu People\u2019s Hospital of Shaoxing","place":["Shaoxing, Zhejiang, 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China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luting","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Shangyu People\u2019s Hospital of Shaoxing","place":["Shaoxing, Zhejiang, China"]},{"name":"School of Medicine, Shaoxing University","place":["Shaoxing, Zhejiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1159\/000547996","article-title":"Tumor mutational burden as a prognostic biomarker for relapse-free survival in hepatocellular carcinoma: insights from long-term follow-up","author":"Miura","year":"2025","journal-title":"Liver Cancer"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn501113-20240412-00200","article-title":"Systemic therapeutic strategies for hepatocellular carcinoma: current status and 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