{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T05:02:04Z","timestamp":1784869324020,"version":"3.55.0"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Esophageal squamous cell carcinoma(ESCC) carries a poor prognosis with low survival rates, frequently due to advanced disease at diagnosis. Colonic metastasis from ESCC is exceptionally rare. This report describes the case of a 68-year-old male with locally advanced ESCC who developed metachronous colonic metastasis during follow-up after initial definitive chemoradiotherapy combined with immunotherapy. Pathological examination of a colonic biopsy confirmed metastatic squamous cell carcinoma with an immunohistochemical profile consistent with esophageal origin. The patient subsequently received systemic chemotherapy followed by combined immunotherapy, achieving a partial response on imaging evaluation. 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