{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T04:56:28Z","timestamp":1776056188893,"version":"3.50.1"},"reference-count":10,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Reports on the efficacy of radiotherapy for perineal extramammary Paget\u2019s disease (EMPD) are limited. We present two cases of locally advanced perineal EMPD successfully treated with radiotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective review was conducted on the clinical presentation, management, and outcomes of two patients with locally advanced, inoperable perineal EMPD who received radiotherapy at our hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both patients achieved complete clinical and radiological remission following radiotherapy. At the last follow-up in January 2026, neither patient showed any evidence of local recurrence or distant metastasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Radiotherapy is an effective and well-tolerated definitive treatment modality for patients with locally advanced EMPD who are not candidates for or who decline surgical resection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1801166","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T04:38:36Z","timestamp":1776055116000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Complete remission after radiotherapy in two cases of locally advanced extramammary Paget\u2019s disease of the perineum"],"prefix":"10.3389","volume":"16","author":[{"given":"Hui","family":"Ma","sequence":"first","affiliation":[{"name":"West China School of Medicine, Sichuan University, Sichuan University affiliated Chengdu Second People's Hospital, Chengdu Second People's Hospital","place":["Chengdu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohui","family":"Xie","sequence":"additional","affiliation":[{"name":"West China School of Medicine, Sichuan University, Sichuan University affiliated Chengdu Second People's Hospital, Chengdu Second People's Hospital","place":["Chengdu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodong","family":"Peng","sequence":"additional","affiliation":[{"name":"West China School of Medicine, Sichuan University, Sichuan University affiliated Chengdu Second People's Hospital, Chengdu Second People's Hospital","place":["Chengdu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1186\/s13023-021-01715-6","article-title":"Prevalence of extramammary Paget\u2019s disease in urban China: a population-based study","volume":"16","author":"Yin","year":"2021","journal-title":"Orphanet J Rare Dis"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16868","article-title":"Demographic and clinical characteristics of extramammary Paget\u2019s disease patients in Japan from 2000 to 2019","volume":"35","author":"Ghazawi","year":"2020","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol28040260","article-title":"Extramammary Paget\u2019s disease: diagnosis, pathogenesis, and treatment with focus on recent developments","volume":"28","author":"Ishizuki","year":"2021","journal-title":"Curr Oncol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12185","article-title":"Radiation therapy for lymph node metastasis from extramammary Paget\u2019s disease","volume":"28","author":"Hata","year":"2013","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17091507","article-title":"Clinical outcomes and prognostic factors for extramammary Paget\u2019s disease treated with radiation therapy: a multi-institutional observational study","volume":"17","author":"Niwa","year":"2025","journal-title":"Cancers"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1097\/igc.0000000000001237","article-title":"The role of radiotherapy in extramammary Paget disease: a systematic review","volume":"28","author":"Tagliaferri","year":"2018","journal-title":"Int J Gynecol Cancer"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1159\/000506832","article-title":"Nonsurgical treatments for extramammary Paget disease: a systematic review and meta-analysis","volume":"236","author":"Snast","year":"2020","journal-title":"Dermatology"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt478","article-title":"Radiation therapy for extramammary Paget\u2019s disease: treatment outcomes and prognostic factors","volume":"25","author":"Hata","year":"2013","journal-title":"Ann Oncol"},{"key":"B9","article-title":"Definitive radiation therapy for extramammary Paget\u2019s disease","volume":"32","author":"Hata","year":"2012","journal-title":"Anticancer Res"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.17855","article-title":"Japanese Dermatological Association guidelines: clinical questions of guidelines for extramammary Paget disease 2025","volume":"52","author":"Matsushita","year":"2025","journal-title":"J Dermatol"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1801166\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T04:39:00Z","timestamp":1776055140000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1801166\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,13]]},"references-count":10,"alternative-id":["10.3389\/fonc.2026.1801166"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2026.1801166","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,13]]},"article-number":"1801166"}}