{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T05:04:50Z","timestamp":1780031090005,"version":"3.53.1"},"reference-count":51,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Gastric-type endocervical adenocarcinoma (G-EAC) is a mucinous adenocarcinoma with gastric differentiation, and its preoperative diagnosis is challenging due to nonspecific symptoms. Peutz-Jeghers syndrome (PJS) is a rare autosomal dominant disorder characterized by mucocutaneous pigmentation and multiple gastrointestinal hamartomatous polyps, associated with an increased risk of G-EAC and other gynecological malignancies. We report a 44-year-old woman presenting with a 10-year cervical mass and 3-year vaginal discharge. She did not seek further medical attention because the cervical mass was asymptomatic and grew slowly. At age 35, she underwent partial jejunectomy for multiple small bowel polyps and intussusception, and postoperative pathology confirmed PJS. Her ultrasound revealed a 4.9 \u00d7 3.5 \u00d7 3.3\u00a0cm cervical mass, while cervical cytology examination was normal. G-EAC was unexpectedly diagnosed on postoperative pathology following total hysterectomy. Postoperative PET-CT imaging demonstrated pelvic lymph node metastasis. She subsequently underwent radical parametrectomy, bilateral oophorectomy, pelvic lymph node dissection, followed by chemotherapy. We also reviewed previously G-EAC cases with PJS, summarizing the pathogenesis and key points for diagnosis and treatment. We provide an in-depth analysis of the reasons for missed diagnosis of G-EAC and highlight the diagnostic challenges. The aim is to enhance gynecologists\u2019 understanding of G-EAC in patients with PJS.<\/jats:p>","DOI":"10.3389\/fonc.2026.1802736","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T04:48:07Z","timestamp":1780030087000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Gastric-type endocervical adenocarcinoma with Peutz-Jeghers syndrome: a case report and literature review"],"prefix":"10.3389","volume":"16","author":[{"given":"Jinting","family":"Li","sequence":"first","affiliation":[{"name":"Department of Gynecology, Guangxi Medical University First Affiliated Hospital","place":["Nanning, Guangxi, China"]},{"name":"Department of Gynecology, the People\u2019s Hospital of Guangxi Zhuang Autonomous Region","place":["Nanning, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roufei","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Guangxi Medical University First Affiliated Hospital","place":["Nanning, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huisi","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Guangxi Medical University First Affiliated Hospital","place":["Nanning, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Guangxi Medical University First Affiliated Hospital","place":["Nanning, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangtao","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Guangxi Medical University First Affiliated Hospital","place":["Nanning, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-020-0614-0","article-title":"Genetic characteristics of gastrictype mucinous carcinoma of the uterine cervix","volume":"34","author":"Park","year":"2021","journal-title":"Mod Pathol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/his.13993","article-title":"Gastric-type mucinous carcinoma of the cervix and its precursors-historical overview","volume":"76","author":"Mikami","year":"2020","journal-title":"Histopathology"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000532","article-title":"Gastric-type endocervical adenocarcinoma: an aggressive tumor with unusual metastatic patterns and poor prognosis","volume":"39","author":"Karamurzin","year":"2015","journal-title":"Am J Surg Pathol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2013.1527","article-title":"Hereditary gynecological tumors associated with Peutz-Jeghers syndrome (review)","volume":"6","author":"Banno","year":"2013","journal-title":"Oncol Lett"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/s12328-019-01080-9","article-title":"Colon cancer of Peutz-Jeghers syndrome with gallolyticus endocarditis","volume":"13","author":"Miyahara","year":"2020","journal-title":"Clin J Gastroenterol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(80)90074-8","article-title":"Peutz-Jeghers syndrome with \"adenoma Malignum\" of the cervix: a report of two cases","volume":"10","author":"Mcgowan","year":"1980","journal-title":"Gynecologic Oncol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-198509000-00012","article-title":"Extremely well-differentiated adenocarcinoma (\"adenoma Malignum\") of the cervix in a patient with Peutz-Jeghers syndrome","volume":"4","author":"Kaku","year":"1985","journal-title":"Int J Gynecol Pathol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/s0046-8177(86)80208-8","article-title":"Female genital tract tumors in Peutz-Jeghers syndrome","volume":"17","author":"Chen","year":"1986","journal-title":"Hum Pathol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1989.tb03390.x","article-title":"Peutz-Jeghers syndrome in association with adenoma Malignum (minimal deviation adenocarcinoma) of the cervix. 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