{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T05:08:57Z","timestamp":1779253737917,"version":"3.51.4"},"reference-count":55,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>As an innovative surgical approach in the treatment of colorectal cancer, Natural Orifice Specimen Extraction Surgery (NOSES) offers several advantages. To ensure robust scientific comparison through multi-database inquiry, this study conducted a comprehensive bibliometric analysis using dual independent databases to explore research hotspots and future trends in colorectal cancer NOSES.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study employed a cross-database comparison strategy using two independent sources: 432 documents from the Web of Science Core Collection (WoSCC) and 411 documents from PubMed, covering the period from January 2010 to June 2025. The WoSCC dataset served as the primary analysis cohort to establish research trends, while the PubMed database functioned as an independent validation cohort to confirm and cross-verify key findings. Bibliometric analyses of authors, institutions, countries, publishing journals, abstracts, keywords, and cited documents were performed using the Bibliometrix R package, CiteSpace, and VOSviewer. Comparative analyses between the two databases were conducted to ensure robustness and reliability of identified research patterns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The analysis included articles from 576 institutions, 112 journals, and 49 countries. China led global publications with 273 articles, while the United Kingdom achieved the highest citation count (2,306). Surgical Endoscopy emerged as the most prolific journal (46 papers) and the most cited (1,824 citations). Highly cited works predominantly focused on clinical trials and innovative surgical techniques in NOSES for colorectal cancer. Cross-database comparison confirmed that recent key research themes include \u201corifice specimen extraction,\u201d \u201cchemoradiotherapy,\u201d and \u201cpathological outcomes,\u201d reflecting the field\u2019s evolving priorities toward minimally invasive approaches and multidisciplinary integration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study reviewed the research on NOSES for colorectal cancer, providing a reference for subsequent studies. It mapped the research landscape in this field, summarized the current state of research, and offered data support and insights for future development.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1803748","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T04:40:54Z","timestamp":1779252054000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Multi-database bibliometric analysis and cross-database comparison of NOSES research in colorectal cancer: integrated evidence from WoSCC and PubMed"],"prefix":"10.3389","volume":"16","author":[{"given":"Siyuan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of General Surgery, The 989th Hospital of the Joint Logistics Support Force of People\u2019s Liberation Army","place":["Luoyang, Henan, China"]},{"name":"Department of Digestive Surgery, Xijing Hospital of Digestive Diseases, Fourth Military Medical University","place":["Xi\u2019an, Shaanxi, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nutrition, The 989th Hospital of the Joint Logistics Support Force of People\u2019s Liberation Army (PLA)","place":["Luoyang, Henan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boyu","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Digestive Surgery, Xijing Hospital of Digestive Diseases, Fourth Military Medical University","place":["Xi\u2019an, Shaanxi, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The 989th Hospital of the Joint Logistics Support Force of People\u2019s Liberation Army","place":["Luoyang, Henan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The 989th Hospital of the Joint Logistics Support Force of People\u2019s Liberation Army","place":["Luoyang, Henan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The 989th Hospital of the Joint Logistics Support Force of People\u2019s Liberation Army","place":["Luoyang, Henan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.70011","article-title":"Cancer treatment and survivorship statistics, 2025","volume":"75","author":"Wagle","year":"2025","journal-title":"CA Cancer J Clin"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1097\/js9.0000000000002788","article-title":"Long-term outcomes of single-incision laparoscopic surgery for colorectal cancer, a single-center, open label, randomized controlled trial","volume":"111","author":"Song","year":"2025","journal-title":"Int J Surg"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-024-11210-1","article-title":"Trends and outcomes in colorectal cancer surgery: a multicenter cross-sectional study of minimally invasive versus open techniques in Germany","volume":"38","author":"Krieg","year":"2024","journal-title":"Surg Endosc"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1055\/a-2410-3269","article-title":"A modified endoscopic full-thickness resection for early colorectal cancer: An expanded application based on super minimally invasive surgery technology","volume":"56","author":"Zhou","year":"2024","journal-title":"Endoscopy"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/s1470-2045(13)70016-0","article-title":"Laparoscopic versus open surgery for rectal cancer (COLOR II): short-term outcomes of a randomised, phase 3 trial","volume":"14","author":"van der Pas","year":"2013","journal-title":"Lancet Oncol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1007\/s00104-015-0052-6","article-title":"Laparoscopic versus open surgery for rectal cancer: Results after 3 years of the COLOR II study","volume":"86","author":"Reibetanz","year":"2015","journal-title":"Chirurg"},{"key":"B7","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1016\/s2468-1253(22)00248-5","article-title":"Robotic versus laparoscopic surgery for middle and low rectal cancer (REAL): short-term outcomes of a multicentre randomised controlled trial","volume":"7","author":"Feng","year":"2022","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2026.04.003","article-title":"Oncologic outcomes and the impact of minimally invasive surgery in early-stage cervical cancer patients undergoing radical trachelectomy: A retrospective multicenter cohort study from the Korean Gynecologic Oncology Group Study (KGOG 1048)","volume":"208","author":"Kim","year":"2026","journal-title":"Gynecol Oncol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1097\/js9.0000000000001043","article-title":"Comparative long-term outcomes of natural orifice specimen extraction surgery and conventional laparoscopic colectomy for left-sided colorectal cancer: a propensity score-matched analysis","volume":"110","author":"Xu","year":"2024","journal-title":"Int J Surg"},{"key":"B10","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1093\/gastro\/goy055","article-title":"International consensus on natural orifice specimen extraction surgery (NOSES) for colorectal cancer","volume":"7","author":"Guan","year":"2019","journal-title":"Gastroenterol Rep (Oxf)"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i36.12981","article-title":"Laparoscopic natural orifice specimen extraction-colectomy: a systematic review","volume":"20","author":"Wolthuis","year":"2014","journal-title":"World J Gastroenterol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.surge.2016.03.001","article-title":"The 100 most influential manuscripts in colorectal cancer: A bibliometric analysis","volume":"14","author":"Wrafter","year":"2016","journal-title":"Surgeon"},{"key":"B13","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/s11701-025-02391-5","article-title":"Global trends and hotspots in the learning curves of robotic-assisted surgery: a bibliometric and visualization analysis","volume":"19","author":"Zhang","year":"2025","journal-title":"J Robot Surg"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.70389\/pjs.100082","article-title":"Transparency in the reporting of artificial intelligence \u2013 the TITAN guideline","volume":"2","author":"Riaz","year":"2025","journal-title":"Premier J Sci"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001948","article-title":"Transanal total mesorectal excision: International registry results of the first 720 cases","volume":"266","author":"Penna","year":"2017","journal-title":"Ann Surg"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.scib.2022.05.014","article-title":"Short-term and oncological outcomes of natural orifice specimen extraction surgery (NOSES) for colorectal cancer in China: a national database study of 5055 patients","volume":"67","author":"Guan","year":"2022","journal-title":"Sci Bull (Beijing)"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx224","article-title":"Rectal cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up\u2020","volume":"28","author":"Glynne-Jones","year":"2017","journal-title":"ESMO Updated Clin Pract Guidelines"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-010-0965-6","article-title":"NOTES transanal rectal cancer resection using transanal endoscopic microsurgery and laparoscopic assistance","volume":"24","author":"Sylla","year":"2010","journal-title":"Surg Endosc"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1.e1","DOI":"10.1016\/j.ejca.2013.06.048","article-title":"EURECCA colorectal: multidisciplinary management: European consensus conference colon & rectum","volume":"50","author":"van de Velde","year":"2014","journal-title":"Eur J Cancer"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1097\/sla.0000000000000865","article-title":"Transanal total mesorectal excision in rectal cancer: short-term outcomes in comparison with laparoscopic surgery","volume":"261","author":"Fern\u00e1ndez-Hevia","year":"2015","journal-title":"Ann Surg"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3892\/or.2015.4108","article-title":"Genetics, diagnosis and management of colorectal cancer (Review)","volume":"34","author":"De Rosa","year":"2015","journal-title":"Oncol Rep"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx224","article-title":"Rectal cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up","volume":"28","author":"Glynne-Jones","year":"2017","journal-title":"Ann Oncol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1097\/sla.0000000000002653","article-title":"Incidence and risk factors for anastomotic failure in 1594 patients treated by transanal total mesorectal excision: Results from the International TaTME Registry","volume":"269","author":"Penna","year":"2019","journal-title":"Ann Surg"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.11459","article-title":"Transanal total mesorectal excision for rectal cancer has been suspended in Norway","volume":"107","author":"Wasmuth","year":"2020","journal-title":"Br J Surg"},{"key":"B25","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1007\/s00384-024-04704-w","article-title":"Transanal total mesorectal excision: short- and long-term results of four certified colorectal cancer centers in Germany","volume":"39","author":"Grundler","year":"2024","journal-title":"Int J Colorectal Dis"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-025-11878-z","article-title":"Impact of sex differences on risk factors for postoperative complications in transanal endoscopic surgery for rectal cancer: a large-scale Japanese multicenter cohort study","volume":"39","author":"Miyake","year":"2025","journal-title":"Surg Endoscopy Other Interventional Techniques"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1097\/sla.0000000000006374","article-title":"Functional outcomes after transanal total mesorectal excision (taTME) for rectal cancer","volume":"280","author":"Donovan","year":"2024","journal-title":"Ann Surg"},{"key":"B28","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s00384-024-04646-3","article-title":"Low anterior resection with transanal transection and single-stapled anastomosis: technical aspects and initial results","volume":"39","author":"L\u00f3pez","year":"2024","journal-title":"Int J Colorectal Dis"},{"key":"B29","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1007\/s00464-019-06750-w","article-title":"Structured training pathway and proctoring; multicenter results of the implementation of transanal total mesorectal excision (TaTME) in the Netherlands","volume":"34","author":"Veltcamp Helbach","year":"2020","journal-title":"Surg Endosc"},{"key":"B30","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1007\/s11701-025-02460-9","article-title":"Comparing the perioperative, postoperative, and oncological outcomes between robotic and transanal total mesorectal excision for rectal cancer: an updated systematic review and meta-analysis of prospective studies with a subgroup analysis for overweight patients","volume":"19","author":"Kossenas","year":"2025","journal-title":"J Rob Surg"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.24276","article-title":"Transanal vs laparoscopic total mesorectal excision and 3-year disease-free survival in rectal cancer: The TaLaR randomized clinical trial","volume":"333","author":"Zeng","year":"2025","journal-title":"JAMA-Journal Am Med Assoc"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.00946","article-title":"Comparison of NOSES and conventional laparoscopic surgery in colorectal cancer: Bacteriological and oncological concerns","volume":"10","author":"Ouyang","year":"2020","journal-title":"Front Oncol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/sla.0000000000005523","article-title":"Morbidity, mortality, and pathologic outcomes of transanal versus laparoscopic total mesorectal excision for rectal cancer short-term outcomes from a multicenter randomized controlled trial","volume":"277","author":"Liu","year":"2023","journal-title":"Ann Surg"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.cireng.2014.01.027","article-title":"Transanal versus laparoscopic total mesorectal excision for mid and low rectal cancer (Ta-LaTME study): multicentre, randomized, open-label trial","volume":"110","author":"Serra-Aracil","year":"2023","journal-title":"Br J Surg"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-024-10995-5","article-title":"Robotic natural orifice specimen extraction surgery versus robotic transabdominal specimen extraction surgery for early-stage rectal cancer: a multicenter propensity score-matched analysis (in China)","volume":"38","author":"Liu","year":"2024","journal-title":"Surg Endosc"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14153803","article-title":"Artificial intelligence in colorectal cancer surgery: Present and future perspectives","volume":"14","author":"Quero","year":"2022","journal-title":"Cancers (Basel)"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2016.10.024","article-title":"Transanal total mesorectal excision (TaTME) for rectal cancer: Step by step description of the surgical technique for a two-teams approach","volume":"43","author":"Arroyave","year":"2017","journal-title":"Eur J Surg Oncol (EJSO)"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2021.106196","article-title":"The natural orifice specimen extraction surgery compared with conventional laparoscopy for colorectal cancer: A meta-analysis of efficacy and long-term oncological outcomes","volume":"97","author":"Wang","year":"2022","journal-title":"Int J Surg"},{"key":"B39","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1001\/jamasurg.2018.3752","article-title":"Long-term oncological and functional outcomes of chemoradiotherapy followed by organ-sparing transanal endoscopic microsurgery for distal rectal cancer the CARTS study","volume":"154","author":"Stijns","year":"2019","journal-title":"JAMA Surg"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-018-4057-6","article-title":"Quality of life after surgery for rectal cancer: a comparison of functional outcomes after transanal and laparoscopic approaches","volume":"23","author":"Bjoern","year":"2019","journal-title":"J Gastrointest Surg"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-020-01934-8","article-title":"Meta-analysis of natural orifice specimen extraction versus conventional laparoscopy for colorectal cancer","volume":"406","author":"Lin","year":"2021","journal-title":"Langenbecks Arch Surg"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.21037\/jgo.2020.03.05","article-title":"Clinical efficacy and quality of life after transrectal natural orifice specimen extraction for the treatment of middle and upper rectal cancer","volume":"11","author":"Zhu","year":"2020","journal-title":"J Gastrointest Oncol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1007\/s00384-023-04591-7","article-title":"Is survival after transanal total mesorectal excision (taTME) worse than that after traditional total mesorectal excision? A retrospective propensity score-adjusted cohort study","volume":"39","author":"Ammann","year":"2024","journal-title":"Int J Colorectal Dis"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1097\/sle.0000000000000438","article-title":"Totally laparoscopic resection for low sigmoid and rectal cancer using natural orifice specimen extraction techniques","volume":"27","author":"Shimizu","year":"2017","journal-title":"Surg Laparoscopy Endoscopy Percutaneous Techniques"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2008.05.011","article-title":"Natural orifice translumenal endoscopic surgery","volume":"88","author":"Bergman","year":"2008","journal-title":"Surg Clin North Am"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-015-4089-x","article-title":"Intra-abdominal bacterial contamination in TAMIS total mesorectal excision for rectal carcinoma: a prospective study","volume":"29","author":"Velthuis","year":"2015","journal-title":"Surg Endoscopy Other Interventional Techniques"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2023.1340869","article-title":"Short-term clinical outcomes and five-year survival analysis of laparoscopic-assisted transanal natural orifice specimen extraction versus conventional laparoscopic surgery for sigmoid and rectal cancer: a single-center retrospective study","volume":"10","author":"Zheng","year":"2023","journal-title":"Front Surg"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1309390","article-title":"Transvaginal access for NOTES: a cohort study of microbiological colonization and contamination","volume":"44","author":"Linke","year":"2012","journal-title":"Endoscopy"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2019.05.034","article-title":"A multicenter study evaluating natural orifice specimen extraction surgery for rectal cancer","volume":"243","author":"Liu","year":"2019","journal-title":"J Surg Res"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-022-09435-z","article-title":"Clinical outcomes of laparoscopic-assisted natural orifice specimen extraction colectomy using a Cai tube for left-sided colon cancer: a prospective randomized trial","volume":"37","author":"Xu","year":"2023","journal-title":"Surg Endosc"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn441530-20220129-00040","article-title":"Comparison between laparoscopic-assisted natural orifice specimen extraction surgery and conventional laparoscopic surgery for left colorectal cancer: a randomized controlled study with 3-year follow-up results","volume":"25","author":"Chen","year":"2022","journal-title":"Zhonghua Wei Chang Wai Ke Za Zhi"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1089\/lap.2019.0828","article-title":"Transanal versus laparoscopic total mesorectal excision: a comparative prospective clinical trial from two centers","volume":"30","author":"Zuhdy","year":"2020","journal-title":"J Laparoendoscopic Advanced Surg Techniques"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.11287","article-title":"Norwegian moratorium on transanal total mesorectal excision","volume":"106","author":"Larsen","year":"2019","journal-title":"Br J Surg"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.3390\/jpm11060584","article-title":"Robotic transanal total mesorectal excision (RTaTME): state of the art","volume":"11","author":"Rondelli","year":"2021","journal-title":"J Personalized Med"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.251496","article-title":"Toward broader clinical adoption of photon-counting CT: where we stand according to high-impact literature","volume":"319","author":"Sahbaee","year":"2026","journal-title":"Radiology"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1803748\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T04:41:03Z","timestamp":1779252063000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1803748\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,20]]},"references-count":55,"alternative-id":["10.3389\/fonc.2026.1803748"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2026.1803748","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,20]]},"article-number":"1803748"}}