{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T02:55:56Z","timestamp":1777949756869,"version":"3.51.4"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Gastric metastases are rare, accounting for only 0.2%\u20130.7% of gastric malignancies. Gastric metastasis from primary popliteal fossa leiomyosarcoma (LMS) has not been previously reported. We report a 60-year-old female who presented with hematemesis and severe anemia, with a past medical history of right popliteal fossa LMS resection. Imaging and endoscopy revealed a bleeding nodular lesion in the gastric body. Pathology and immunohistochemistry (SMA+\/Desmin+, CD117\u2013\/DOG-1\u2013) confirmed metastatic LMS to the stomach, with suspected pancreatic and bone metastases. The patient underwent emergency embolization for active bleeding, followed by laparoscopic partial gastrectomy and systemic chemotherapy. At the 9-month follow-up, she remained in good general condition. This case highlights that in patients with a history of malignancy presenting with gastrointestinal bleeding, gastric metastasis should be considered, and multidisciplinary management combined with surgery and systemic therapy can achieve favorable outcomes.<\/jats:p>","DOI":"10.3389\/fonc.2026.1805796","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:25:12Z","timestamp":1777868712000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical management of metastatic gastric tumors: a case report of right popliteal leiomyosarcoma metastasizing to the stomach and literature review"],"prefix":"10.3389","volume":"16","author":[{"given":"Ping","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Chongqing University Three Gorges Hospital, Chongqing University","place":["Chongqing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tun","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Chongqing University Three Gorges Hospital, Chongqing University","place":["Chongqing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Chongqing University Three Gorges Hospital, Chongqing University","place":["Chongqing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofei","family":"Bi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Chongqing University Three Gorges Hospital, Chongqing University","place":["Chongqing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Chongqing University Three Gorges Hospital, Chongqing University","place":["Chongqing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zecheng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Chongqing University Three Gorges Hospital, Chongqing University","place":["Chongqing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengting","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Chongqing University Three Gorges Hospital, Chongqing University","place":["Chongqing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2022.0008","article-title":"Gastric cancer, version 2.2022, NCCN clinical practice guidelines in oncology","volume":"20","author":"Ajani","year":"2022","journal-title":"J Natl Compr Canc Netw"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-013-0671-9","article-title":"Clinicopathological features and treatment outcomes of metastatic tumors in the stomach","volume":"44","author":"Namikawa","year":"2014","journal-title":"Surg Today"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-14960","article-title":"Metastatic tumors to the stomach: analysis of 54 patients diagnosed at endoscopy and 347 autopsy cases","volume":"33","author":"Oda","year":"2001","journal-title":"Endoscopy"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900401)65:7<1596::aid-cncr2820650724>3.0.co;2-5","article-title":"Hematogenous metastases to the stomach. 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