{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T05:02:27Z","timestamp":1777006947296,"version":"3.51.4"},"reference-count":19,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>\n                    The presence of malignant heterologous elements and malignant transformation of the epithelial component in phyllodes tumor (PT) is infrequent. The co-existence of both features within a single malignant PT is exceptionally rare and poorly documented. We report a unique case of a 57-year-old female with a malignant PT exhibiting both low-grade ductal carcinoma\n                    <jats:italic>in situ<\/jats:italic>\n                    (DCIS) and heterologous chondrosarcomatous differentiation. This case underscores the diagnostic challenges and therapeutic considerations for this complex tumor entity, highlighting the critical importance of extensive histopathological sampling.\n                  <\/jats:p>","DOI":"10.3389\/fonc.2026.1807860","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T04:30:25Z","timestamp":1777005025000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case report: A case of malignant phyllodes tumor of the breast with concurrent epithelial malignancy and heterologous chondrosarcomatous differentiation"],"prefix":"10.3389","volume":"16","author":[{"given":"Jie","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Breast, Thyroid and Vascular Surgery, Hubei Provincial Clinical Research Center for Umbilical Cord Blood Hematopoietic Stem Cells, Taihe Hospital, Hubei University of Medicine","place":["Shiyan, Hubei, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Breast, Thyroid and Vascular Surgery, Hubei Provincial Clinical Research Center for Umbilical Cord Blood Hematopoietic Stem Cells, Taihe Hospital, Hubei University of Medicine","place":["Shiyan, Hubei, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Breast, Thyroid and Vascular Surgery, Hubei Provincial Clinical Research Center for Umbilical Cord Blood Hematopoietic Stem Cells, Taihe Hospital, Hubei University of Medicine","place":["Shiyan, Hubei, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Breast, Thyroid and Vascular Surgery, Hubei Provincial Clinical Research Center for Umbilical Cord Blood Hematopoietic Stem 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