{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T05:08:39Z","timestamp":1780463319537,"version":"3.54.1"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to assess the noninferiority of biparametric MRI (bpMRI) compared to multiparametric MRI (mpMRI) using Prostate Imaging Reporting and Data System (PI-RADS) in diagnosing prostate cancer (PCa). Additionally, we compared diagnostic performance of bpMRI and mpMRI between expert and non-expert readers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 319 men with abnormal serum prostate-specific antigen (PSA) were included in the study and underwent mpMRI examinations. Two expert readers and two non-expert readers sequentially assessed bpMRI and mpMRI using the PI-RADS scoring system, respectively. The noninferiority of bpMRI versus mpMRI was evaluated using the area under the receiver operating characteristic curve (AUROC) alongside the sensitivity and specificity at a threshold of PI-RADS 3. The diagnostic performance and inter-observer agreement of bpMRI and mpMRI were compared between expert and non-expert readers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The prevalence of clinically significant PCa (csPCa) was 55.5% (177\/319), bpMRI showed noninferior diagnostic performance to mpMRI in AUROC (0.896 [95% CI, 0.879-0.943] vs 0.911 [95% CI, 0.861-0.931]; difference of -1.5% [95% CI, -3.1% to 0.1%], p &amp;lt; 0.001), alongside sensitivity (92.8 [95% CI, 90.1-95.6] vs 93.8 [95% CI, 91.2-96.6]; difference of -1.0% [95% CI, -2.0% to 0.0%], p &amp;lt; 0.001) and specificity (69.4 [95% CI, 63.6-73.9] vs 73.1[95% CI, 67.1-76.9]; difference of -3.5% [95% CI, -6.1% to -1.4%], p &amp;lt; 0.01) at a threshold of PI-RADS 3. In bpMRI interpretation, specificity showed significant differences among readers (P\u00a0=\u00a00.001); expert readers (32.7%, 209\/638) and non-expert readers (37.0%, 236\/638) showed significant differences in PI-RADS 3 (P\u00a0=\u00a00.01) and moderate agreement (0.64 [0.53-0.71]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The diagnostic performance of bpMRI in detecting csPCa was noninferior to that of mpMRI in a selected high-risk cohort of men with abnormal serum PSA. Limited additional benefits of DCE were observed for non-expert readers. Specialized system training of PI-RADS for non-experts or diagnosis under the supervision of expert radiologists might be better alternatives.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1808035","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T04:53:44Z","timestamp":1780462424000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic performance of biparametric versus multiparametric MRI for prostate cancer: a noninferiority, confirmatory observer study"],"prefix":"10.3389","volume":"16","author":[{"given":"Xingyu","family":"Fang","sequence":"first","affiliation":[{"name":"Department of Radiology, the 305 Hospital of PLA","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Laboratory, The 305 Hospital of PLA","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Radiology, the 305 Hospital of PLA","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology, the 305 Hospital of PLA","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Radiology, the 305 Hospital of PLA","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology, the 305 Hospital of PLA","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Radiology, the 305 Hospital of PLA","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology, the 305 Hospital of PLA","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30569-2","article-title":"Use of prostate systematic and targeted biopsy on the basis of multiparametric MRI in biopsy-naive patients (MRI-FIRST): a prospective, multicentre, paired diagnostic study","volume":"20","author":"Rouvi\u00e8re","year":"2019","journal-title":"Lancet Oncol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd012663.pub2","article-title":"Prostate MRI, with or without MRI-targeted biopsy, and systematic biopsy for detecting prostate cancer","volume":"4","author":"Drost","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2024.03.027","article-title":"EAU-EANM-ESTRO-ESUR-ISUP-SIOG guidelines on prostate cancer-2024 update. 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