{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T05:43:56Z","timestamp":1785908636580,"version":"3.56.0"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To present a family of novel brachytherapy-based device concepts that address the geometric, dosimetric, and integrative limitations of current localized radiation therapy, aiming to improve local tumor control while reducing collateral exposure. This is a concept and design paper, not a clinical or dosimetric validation study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Multiple device designs were developed over more than a decade, focused on two prototypical clinical settings: intraluminal applicators for the esophagus and intracavitary applicators for the post-resection glioblastoma cavity. Designs include hollow rectangular ribbon (HRR) catheters that encase fluid, gel, or wire isotope sources; modified stents with anti-slippage geometry, dynamic flares, and reservoirs; and a multifunctional cavity device combining brachytherapy with continuous hyperthermia and pressure-modulated diffusional drug, immunotherapy, and nanoparticle delivery. Bench prototypes were constructed and evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Bench observations demonstrated manipulation of a thermal gradient by modulating the warm source, and an approximately 15-fold increase in dislodgement force for a representative anti-slippage geometry. The designs are further intended to flatten the near-surface dose gradient by expanding the effective source distribution and to integrate drainage, infusion, and pressure modulation in a single device; these dosimetric and integrative benefits are design expectations not yet experimentally tested.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These concepts may improve local control where recurrence concentrates near the resection or stented surface, as in post-resection glioblastoma and obstructive luminal malignancies. The integration of continuous hyperthermia, local diffusion of chemotherapeutic, immunotherapeutic, and protective agents, and pressure-modulated nanoparticle delivery is particularly attractive. The concepts are intended to stimulate further bench, computational, animal, and clinical investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1812448","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T04:46:20Z","timestamp":1785905180000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Brachytherapy-based multimodality cancer treatment: a concept and design perspective on devices to address the challenges of localized radiation therapy"],"prefix":"10.3389","volume":"16","author":[{"given":"Joshua J.","family":"Herskovic","sequence":"first","affiliation":[{"name":"Department of Surgery, Baptist Health South Florida","place":["Boynton Beach, FL, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnold M.","family":"Herskovic","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology (Emeritus), 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