{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T05:10:45Z","timestamp":1779340245884,"version":"3.51.4"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Delayed cerebral radiation necrosis (CRN) is a condition characterized by fibrinoid necrosis, blood-brain barrier disruption, and demyelination due to endothelial cell and oligodendrocyte injury as a result of radiation therapy. The presentation is variable as neurologic manifestations depend on the site of the lesion. This case report describes a rare presentation of delayed CRN years after diagnosis and treatment of osteoradionecrosis of the skull base. It highlights the importance of keeping this diagnosis on the differential for patients with a history of radiation therapy to the head or neck who present with new neurological symptoms and\/or radiographic findings, even if prior sites of necrosis were treated and there was no subsequent re-irradiation. This report also underscores how CRN is often difficult to distinguish from tumor progression and how assessment of treatment response may help inform the diagnosis.<\/jats:p>","DOI":"10.3389\/fonc.2026.1814632","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T04:44:46Z","timestamp":1779338686000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Delayed cerebral radiation necrosis after osteoradionecrosis of the skull base: a case report"],"prefix":"10.3389","volume":"16","author":[{"given":"Maria A.","family":"Jacome","sequence":"first","affiliation":[{"name":"Department of Neurology, Florida International University Herbert Wertheim College of Medicine","place":["Miami, FL, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Khalil","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of South Florida Morsani College of Medicine","place":["Tampa, FL, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neena","family":"Viswanathan","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of South Florida Morsani College of Medicine","place":["Tampa, FL, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheethal","family":"Cyriac","sequence":"additional","affiliation":[{"name":"Department of Neuro-Oncology, H. 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