{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T05:10:08Z","timestamp":1779167408176,"version":"3.51.4"},"reference-count":13,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>\n                    Uterine leiomyoma is a common benign tumor of the uterus and typically demonstrates low FDG uptake on\n                    <jats:sup>18<\/jats:sup>\n                    F-FDG PET\/CT. Intense FDG uptake in a uterine mass is generally considered suggestive of malignancy. Here, we report a case of uterine leiomyoma in a patient who presented with multiple areas of abnormal bone density throughout the body. To evaluate the possibility of bone metastases and to identify a potential primary tumor,\n                    <jats:sup>18<\/jats:sup>\n                    F-FDG PET\/CT was performed. Incidentally, a uterine mass with markedly increased FDG uptake was detected, raising strong suspicion of a uterine malignancy. However, postoperative histopathological examination ultimately confirmed the diagnosis of a benign uterine leiomyoma.\n                  <\/jats:p>","DOI":"10.3389\/fonc.2026.1817471","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T04:21:45Z","timestamp":1779164505000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case report: A case of benign uterine leiomyoma with intense 18F-FDG uptake mimicking malignant tumor on PET\/CT"],"prefix":"10.3389","volume":"16","author":[{"given":"Taiping","family":"Liao","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, The Third Hospital of Mianyang(Sichuan Mental Health Center)","place":["Mianyang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoxu","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, The Third Hospital of Mianyang(Sichuan Mental Health Center)","place":["Mianyang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongjun","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, The Third Hospital of Mianyang(Sichuan Mental Health Center)","place":["Mianyang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songsong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Zigong Fourth People\u2019s Hospital","place":["Zigong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"He","sequence":"additional","affiliation":[{"name":"Department of Oncology, The Third Hospital of Mianyang(Sichuan Mental Health Center)","place":["Mianyang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, The Third Hospital of Mianyang(Sichuan Mental Health Center)","place":["Mianyang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1210\/endrev\/bnab039","article-title":"Comprehensive review of uterine fibroids: Developmental origin, pathogenesis, and treatment","volume":"43","author":"Yang","year":"2022","journal-title":"Endocr Rev"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-023-00576-4","article-title":"Advances in PET imaging of cancer","volume":"23","author":"Schwenck","year":"2023","journal-title":"Nat Rev Cancer"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000009421","article-title":"Uterine fibroids with positive 18F-FDG PET\/CT image and significantly increased CA19-9: A case report","volume":"96","author":"Ma","year":"2017","journal-title":"Med (Baltimore)"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.09.4074","article-title":"Spectrum of FDG PET\/CT findings of uterine tumors","volume":"195","author":"Kitajima","year":"2010","journal-title":"AJR Am J Roentgenol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000002580","article-title":"Aberrant hypermetabolism of benign uterine leiomyoma on 18F-FDG PET\/CT","volume":"44","author":"Nunes","year":"2019","journal-title":"Clin Nucl Med"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-014-2698-6","article-title":"18F-FDG PET\/CT findings in uterine leiomyomas","volume":"41","author":"Jehanno","year":"2014","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2017.05.003","article-title":"Efficacy of PET\/CT to exclude leiomyoma in patients with lesions suspicious for uterine sarcoma on MRI","volume":"56","author":"Kusunoki","year":"2017","journal-title":"Taiwan J Obstet Gynecol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-007-0787-7","article-title":"The utility of diffusion-weighted MR imaging for differentiating uterine sarcomas from benign leiomyomas","volume":"18","author":"Tamai","year":"2008","journal-title":"Eur Radiol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2023.111217","article-title":"Leiomyoma or sarcoma? MRI performance in the differential diagnosis of sonographically suspicious uterine masses","volume":"170","author":"Valletta","year":"2024","journal-title":"Eur J Radiol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2020191658","article-title":"Diagnostic algorithm to differentiate benign atypical leiomyomas from Malignant uterine sarcomas with diffusion-weighted MRI","volume":"297","author":"Abdel Wahab","year":"2020","journal-title":"Radiology"},{"key":"B11","doi-asserted-by":"publisher","first-page":"499","DOI":"10.2967\/jnumed.112.113472","article-title":"18F-FES and 18F-FDG PET for differential diagnosis and quantitative evaluation of mesenchymal uterine tumors: Correlation with immunohistochemical analysis","volume":"54","author":"Zhao","year":"2013","journal-title":"J Nucl Med"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/s12149-012-0597-0","article-title":"18F-FLT PET performs better than 18F-FDG PET in differentiating Malignant uterine corpus tumors from benign leiomyoma","volume":"26","author":"Yamane","year":"2012","journal-title":"Ann Nucl Med"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1007\/s12149-008-0184-6","article-title":"Incidence and characteristics of uterine leiomyomas with FDG uptake","volume":"22","author":"Nishizawa","year":"2008","journal-title":"Ann Nucl Med"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1817471\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T04:22:01Z","timestamp":1779164521000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1817471\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,19]]},"references-count":13,"alternative-id":["10.3389\/fonc.2026.1817471"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2026.1817471","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,19]]},"article-number":"1817471"}}