{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:20:50Z","timestamp":1791588050442,"version":"4.3.4"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:title>Background<\/jats:title>\n                  <jats:p>Patients with advanced breast cancer endure a high symptom burden and impaired quality of life. This study evaluated the impact of Early Integrated Palliative Care (EIPC) on these outcomes. Methods: A retrospective cohort study analyzed patients with advanced breast cancer treated between November 2018 and December 2021. Patients were categorized into an EIPC group or a usual care group based on the care model received. Symptom burden (SDS) and sleep quality (PSQI) were assessed at baseline, 6, 12, 18, and 24 weeks. Quality of life (FACT-B), hope (HHI), and anxiety\/depression (HADS) were evaluated at baseline and 24 weeks. End-of-life chemotherapy rates were recorded. Results: Of 200 included patients, 88 received EIPC, and 112 received usual care. The EIPC group demonstrated significantly lower SDS scores from week 6 onward (24 weeks: 27.57 vs. 29.71, P\u00a0=\u00a00.002) and lower PSQI scores (24 weeks: 7.21 vs. 8.19, P\u00a0=\u00a00.002). At 24 weeks, the EIPC group had significantly higher FACT-B scores in physical, social\/family, emotional, and functional well-being domains (all P&amp;lt;0.05), higher HHI scores (positive attitude: 13.06 vs. 12.44, P\u00a0=\u00a00.004), and lower HADS depression (6.45 vs. 7.36, P\u00a0=\u00a00.002) and anxiety scores (6.23 vs. 7.18, P\u00a0=\u00a00.001). The rate of chemotherapy in the last 6 weeks of life was significantly lower in the EIPC group (20.45% vs. 40.18%, P\u00a0=\u00a00.003). Conclusion: EIPC alleviates symptom burden, improves quality of life, psychological well-being, and sleep, and promotes more goal-concordant end-of-life care in patients with advanced breast cancer.<\/jats:p>","DOI":"10.3389\/fonc.2026.1817750","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T04:45:02Z","timestamp":1778647502000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["The impact of early integrated palliative care on symptom burden and quality of life in patients with advanced breast cancer"],"prefix":"10.3389","volume":"16","author":[{"given":"Shiying","family":"Li","sequence":"first","affiliation":[{"name":"The First Hospital of Hebei Medical University","place":["Shijiazhuang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weina","family":"Wang","sequence":"additional","affiliation":[{"name":"Breast Center, the Fourth Hospital of Hebei Medical University","place":["Shijiazhuang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengxin","family":"Bai","sequence":"additional","affiliation":[{"name":"The First Hospital of Hebei Medical University","place":["Shijiazhuang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Wang","sequence":"additional","affiliation":[{"name":"Breast Center, the Fourth Hospital of Hebei Medical University","place":["Shijiazhuang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1002\/cai2.70032","article-title":"Guidelines for the diagnosis and treatment of advanced breast cancer in China (2024 edition)","volume":"4","year":"2025","journal-title":"Cancer Innovation"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-025-01866-6","article-title":"The gap between 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