{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T05:09:01Z","timestamp":1779426541883,"version":"3.53.1"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, with near-universal recurrence despite multimodality treatment. Increasing evidence suggests that the subventricular zone (SVZ), a major neural stem cell niche, may contribute to tumor aggressiveness, recurrence, and therapeutic resistance. However, the clinical significance of incidental SVZ irradiation remains controversial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective analytical study included 28 consecutive patients with histologically confirmed GBM treated uniformly with maximal safe resection followed by temozolomide-based chemoradiation using IMRT\/VMAT. Ipsilateral, contralateral, and bilateral SVZs were retrospectively contoured, and dosimetric parameters were extracted. Survival outcomes were correlated with SVZ contact and radiation dose. The primary endpoints were overall survival (OS) and progression-free survival (PFS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>With a median follow-up of 14.5 months, median OS and PFS were 13 months and 6.5 months, respectively. Tumors contacting the SVZ were associated with inferior OS (7 vs 15 months; p = 0.044) and shorter PFS. On univariate analysis, SVZ contact was associated with worse survival (HR 4.04). Among patients with SVZ-contacting tumors, a higher ipsilateral SVZ dose (\u226552.14 Gy) showed a trend toward improved OS (p = 0.04). However, given the limited number of events, these findings should be interpreted with caution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SVZ contact appears to identify a higher-risk subgroup of GBM patients. Higher incidental irradiation of the ipsilateral SVZ may be associated with improved survival; however, due to the small sample size and limited events, these findings are exploratory and hypothesis-generating. Larger prospective studies are required before clinical implementation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1818058","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T04:43:18Z","timestamp":1779424998000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of subventricular zone irradiation in glioblastoma patients"],"prefix":"10.3389","volume":"16","author":[{"given":"Laya K.","family":"Pillai","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, The Gujarat Cancer & Research Institute","place":["Ahmedabad, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maitrik J.","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, The Gujarat Cancer & Research Institute","place":["Ahmedabad, 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