{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T05:06:57Z","timestamp":1779944817131,"version":"3.53.1"},"reference-count":48,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>High body mass index (BMI) has been identified as a critical factor contributing to the occurrence of ovarian cancer and uterine cancer. This study intended to analyze the global epidemiological trends of ovarian cancer and uterine cancer attributable to high BMI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data on early-onset (&amp;lt;50 years old) and late-onset (\u226550 years old) ovarian cancer and uterine cancer attributable to high BMI from 1990 to 2021 were extracted from the Global Burden of Disease (GBD) 2021. Mortality, disability-adjusted life-years (DALYs), and average annual percentage change (AAPC) were applied to assess the disease burden. Future trends in mortality and DALYs were projected using the Bayesian age-period-cohort analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From 1990 to 2021, the DALYs of early-onset and late-onset ovarian cancer and uterine cancer attributable to high BMI all showed an upward trend, with AAPCs of 1.363 (95%CI: 1.336 to 1.400), 0.405 (95%CI: 0.382 to 0.431), 0.560 (95%CI: 0.490 to 0.637), and 0.300 (95%CI: 0.254 to 0.342), respectively. The mortality outcomes for ovarian cancer and uterine cancer were similar to those observed in DALYs. The age-standardized rates of mortality and DALYs for late-onset ovarian cancer and uterine cancer were significantly higher than those for their early-onset cases. Among regions of different socio-demographic index (SDI), the mortality and DALYs of early-onset and late-onset ovarian cancer exhibited a declining trend in high-SDI regions, while they showed an increasing trend in other SDI regions. For uterine cancer, the mortality and DALYs presented a downward trend in high-middle-SDI regions. Furthermore, the mortality and DALYs for ovarian cancer and uterine cancer are projected to continue rising from 2022 to 2050.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The global burden of early-onset and late-onset ovarian cancer and uterine cancer attributable to high BMI has shown an upward trend from 1990 to 2021 and is projected to continue rising in the future.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1821189","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T04:53:38Z","timestamp":1779944018000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Global, regional, and national burden of ovarian cancer and uterine cancer attributable to high BMI, 1990-2021: analysis of data from the global burden of disease study 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