{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:44:19Z","timestamp":1790603059899,"version":"4.1.0"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate the pathological morphology, immunophenotype, and molecular genetic characteristics of recurrent low-grade endometrial stromal sarcoma (LG-ESS) through the analysis of paired primary and recurrent tumor samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A single-center retrospective analysis was conducted using the clinical data, pathological morphology, immunohistochemical results of estrogen receptor, progesterone receptor (PR), CD10, Ki-67, and fluorescence\n                      <jats:italic>in situ<\/jats:italic>\n                      hybridization findings for\n                      <jats:italic>JAZF1<\/jats:italic>\n                      and\n                      <jats:italic>PHF1<\/jats:italic>\n                      gene rearrangements in paired tumor tissues from four patients with LG-ESS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients\u2019 ages ranged from 22 to 34 years. All cases showed consistent\n                      <jats:italic>JAZF1<\/jats:italic>\n                      or\n                      <jats:italic>PHF1<\/jats:italic>\n                      gene rearrangements in both primary and recurrent tumors. However, immunophenotypic alterations were observed during recurrence: one recurrent lesion showed loss of PR expression accompanied by a decreased Ki-67 index, whereas another demonstrated loss of CD10 expression. The median follow-up time was 84 months (range, 36\u2013144 months). The recurrence interval ranged from 3 to 12 years, and all patients remained alive following comprehensive treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case series indicates that core driver gene rearrangements remain stable during recurrence in LG-ESS, whereas immunophenotypic evolution may occur in some cases. These preliminary findings suggest that the re-evaluation of biomarkers such as hormone receptors at recurrence may provide valuable guidance for individualized treatment selection (e.g., hormonal therapy). Given the characteristic tendency for late recurrence in LG-ESS, long-term follow-up is essential.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1823340","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T04:29:17Z","timestamp":1780374557000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case series analysis of immunophenotypic evolution during recurrence of low-grade endometrial stromal sarcoma: implications for molecular stability and clinical management"],"prefix":"10.3389","volume":"16","author":[{"given":"Jing","family":"Li","sequence":"first","affiliation":[{"name":"Obstetrics & Gynecology Hospital of Fudan University, Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases","place":["Shanghai, 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