{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:06:33Z","timestamp":1790139993980,"version":"4.0.1"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neurofibromatosis type 1 (NF1) is a neurocutaneous genetic disorder. Plexiform neurofibromas (PNFs), occurring in a subset of patients, carry a risk of significant hemorrhage, which can be life-threatening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>A 61-year-old woman with NF1 presented with a rapidly enlarging, painful left buttock mass after trauma. Imaging confirmed a PNF with intratumoral hemorrhage. She underwent preoperative digital subtraction angiography (DSA) with embolization of tumor-feeding arteries, followed by successful complete surgical resection. At 6-month follow-up, the patient remained free of recurrent hemorrhage, with satisfactory wound healing and significant improvement in pain and mobility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Giant plexiform neurofibromas complicated by acute hemorrhage represent a rare but clinically challenging manifestation of NF1. This case demonstrates that a staged strategy combining preoperative DSA-guided embolization and surgical resection within a multidisciplinary framework can effectively control bleeding and optimize perioperative safety. Comprehensive risk assessment, including vigilance for thromboembolic complications, is essential in high-risk surgical patients. Given the lifelong risk of malignant transformation, long-term surveillance and consideration of targeted therapy remain critical, although real-world accessibility may limit implementation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Preoperative embolization followed by resection represents a safe and effective multidisciplinary strategy for controlling acute, life-threatening hemorrhage in NF1-associated PNF. Similarly, perioperative surveillance and long-term follow-up remain essential for achieving optimal clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1826614","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:43:10Z","timestamp":1790138590000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Preoperative DSA-guided embolization combined with surgical resection for the treatment of intratumoral hemorrhage in plexiform neurofibroma: a case report"],"prefix":"10.3389","volume":"16","author":[{"given":"Yuzhe","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University","place":["Wenzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqiong","family":"Wang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University","place":["Wenzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiwen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University","place":["Wenzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University","place":["Wenzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuyue","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University","place":["Wenzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeru","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Wound Repair, The First Affiliated Hospital of Wenzhou Medical University","place":["Wenzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/s1474-4422(14)70063-8","article-title":"Neurofibromatosis type 1: a multidisciplinary approach to care","volume":"13","author":"Hirbe","year":"2014","journal-title":"Lancet Neurol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"3955","DOI":"10.3390\/cancers17243955","article-title":"The pathogenesis of the neurofibroma-to-sarcoma transition in neurofibromatosis type I: from molecular profiles to diagnostic applications","volume":"17","author":"Busciglio","year":"2025","journal-title":"Cancers 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