{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:03:39Z","timestamp":1777633419037,"version":"3.51.4"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Proximal gastrectomy preserves gastric function but is limited by postoperative reflux. The double flap technique (DFT) offers an anti-reflux reconstruction, yet prospective evidence in China is lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective, single-center phase II study evaluated the safety and efficacy of laparoscopic proximal gastrectomy with DFT (LPG-DFT) for early proximal gastric cancer. Primary outcome was reflux esophagitis at 12 months; secondary outcomes included perioperative results, nutrition, and quality of life (QoL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty patients underwent LPG-DFT without intraoperative complications or conversion. All achieved R0 resection, with a mean of 27.3 \u00b1 8.9 lymph nodes harvested. No patient developed Los Angeles grade B or higher reflux at 12 months. Nutritional parameters showed only slight, nonsignificant declines. QoL scores decreased temporarily at 3 months but returned to baseline by 12 months. No major complications or mortality occurred.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LPG-DFT is safe, effectively prevents reflux, and preserves nutrition and QoL, supporting its use in early proximal gastric cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1830984","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T04:35:17Z","timestamp":1777437317000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Laparoscopic radical proximal gastrectomy with double flap technique for early proximal gastric cancer: a prospective, phase II study"],"prefix":"10.3389","volume":"16","author":[{"given":"Shengning","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Surgery, The Affiliated Guangdong Second 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China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, The Affiliated Guangdong Second Provincial General Hospital of Jinan University","place":["Guangzhou, Guangdong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanghai","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, The Affiliated Guangdong Second Provincial General Hospital of Jinan University","place":["Guangzhou, Guangdong, China"]},{"name":"Department of Gastrointestinal Surgery, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University","place":["Guangzhou, Guangdong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianan","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, The Affiliated Guangdong Second Provincial General Hospital of Jinan 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