{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T07:03:05Z","timestamp":1779692585179,"version":"3.53.1"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>The local recurrence rate after radical resection of rectal cancer is approximately 5%-20%, and can increase to 20%-35% in elderly patients who do not receive radiotherapy or chemotherapy. Recurrence is frequently complicated by intestinal obstruction, with a median survival of only 6\u20137 months. Herein, we report a case of an elderly patient who developed local recurrence with complete intestinal obstruction 4 months after radical resection of rectal cancer. After obstruction relief achieved by intestinal stent placement, a comprehensive treatment strategy was implemented based on genetic testing and multidisciplinary team discussion, consisting of regional intra-arterial infusion chemotherapy combined with deep hyperthermia and bevacizumab, followed by sequential radiotherapy. The patient ultimately achieved complete remission and long-term stable disease.<\/jats:p>","DOI":"10.3389\/fonc.2026.1832384","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T06:06:36Z","timestamp":1779689196000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Regional intra-arterial infusion chemotherapy combined with deep hyperthermia and targeted therapy followed by radiotherapy for recurrence with intestinal obstruction after radical resection of rectal cancer in an elderly patient: a case report of individualized treatment"],"prefix":"10.3389","volume":"16","author":[{"given":"Guangsheng","family":"Zhao","sequence":"first","affiliation":[{"name":"Cancer Interventional Center, Affiliated Zhongshan Hospital of Dalian University","place":["Dalian, Liaoning, 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