{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T05:04:29Z","timestamp":1789535069461,"version":"build-2803163510"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Granulocytic sarcoma (GS) is a rare extramedullary accumulation of myeloid blasts. Cases of GS with isolated intradural presentation sparing the underlying bone are extremely rare.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case description<\/jats:title>\n                    <jats:p>A 75-year-old male patient with a remote history of acute myeloid leukemia (AML) in 30-year remission presented with progressive lumbar radiculopathy. Magnetic Resonance Imaging (MRI) revealed intradural lesions spanning L2\u2013S1, mimicking nerve sheath tumors. The patient underwent emergency laminectomy and resection of a vascular, grayish-green L2 mass adherent to the cauda equina. Immunohistochemistry confirmed it was a GS (MPO+, CD43+, CD68+) with no evidence of bone marrow relapse. Following surgery and consolidation chemotherapy, the patient\u2019s neurological status improved (ASIA C to D). However, he developed disseminated CNS relapse four months later and succumbed to disease progression 7 months postoperatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Isolated intradural GS constitutes a rare manifestation of extramedullary AML relapse and frequently masquerades radiologically as common benign nerve sheath tumors. While urgent surgical decompression facilitates significant neurological recovery, long-term survival is strictly dictated by the efficacy of systemic disease control. Therefore, adopting a multidisciplinary strategy integrating intraoperative frozen-section analysis, rigorous immunohistochemical profiling, and early adjuvant chemotherapy is paramount for avoiding diagnostic delays and optimizing patient outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1832811","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T04:32:00Z","timestamp":1789533120000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Spinal granulocytic sarcoma with both extradural and intradural involvement: a case report"],"prefix":"10.3389","volume":"16","author":[{"given":"Jian","family":"Zhang","sequence":"first","affiliation":[{"name":"Nanjing University of Chinese Medicine","place":["Nanjing, Jiangsu, China"]},{"name":"Wuxi Traditional Chinese Medicine (TCM) Hospital Affiliated to Nanjing University of Chinese Medicine","place":["Wuxi, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao-Guo","family":"Han","sequence":"additional","affiliation":[{"name":"Wuxi Traditional Chinese Medicine (TCM) Hospital Affiliated to Nanjing University of Chinese Medicine","place":["Wuxi, Jiangsu, China"]},{"name":"Wuxi Xishan District Hospital of Traditional Chinese Medicine","place":["Wuxi, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Hao","family":"Ge","sequence":"additional","affiliation":[{"name":"Nanjing University of Chinese Medicine","place":["Nanjing, Jiangsu, China"]},{"name":"Wuxi Traditional Chinese Medicine (TCM) Hospital Affiliated to Nanjing University of Chinese Medicine","place":["Wuxi, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Chen","family":"Zhu","sequence":"additional","affiliation":[{"name":"Wuxi Traditional Chinese Medicine (TCM) Hospital Affiliated to Nanjing University of Chinese Medicine","place":["Wuxi, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Feng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Wuxi Traditional Chinese Medicine (TCM) Hospital Affiliated to Nanjing University of Chinese Medicine","place":["Wuxi, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"B1","article-title":"Granulocytic sarcoma: a systematic review","volume":"3","author":"Yilmaz","year":"2013","journal-title":"Am J Blood Res"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1961.03620120048008","article-title":"Chloroma and related myeloblastic neoplasms","volume":"108","author":"Reardon","year":"1961","journal-title":"Arch Intern Med"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2012.10.014","article-title":"Is there a \u201cgold\u201d standard treatment for patients with isolated myeloid 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