{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:09:40Z","timestamp":1789016980035,"version":"build-2803163510"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To develop and validate a predictive model integrating patient demographics and clinical data for estimating 3-, 4-, and 5-year overall survival in patients with locally advanced cervical squamous cell carcinoma (LACSC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Clinical data from 670 LACSC patients at Shanxi Cancer Hospital were collected and then randomly assigned to a training cohort and an internal validation cohort at a 6:4 ratio by stratified sampling. Independent prognostic factors were identified using LASSO regression and multivariate Cox regression analysis, with which a predictive model was constructed. Model performance was assessed using the concordance index (C-index), receiver operating characteristic (ROC) curves, and calibration curves. Clinical utility was evaluated via decision curve analysis (DCA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A robust prognostic model was developed and visualized as a nomogram comprising six variables: NEUT, MONO, CA125, SII, lymph node metastasis status, and treatment modality. Patients were stratified into high- and low-risk groups based on the median risk score in the training cohort. The high-risk group exhibited significantly poorer overall survival (OS) in both cohorts (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&amp;lt;\u00a00.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A clinical predictive model was established to estimate 3-, 4-, and 5-year survival rates for LACSC patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1833639","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:33:06Z","timestamp":1789014786000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Analysis of prognostic factors in patients with locally advanced cervical squamous cell carcinoma and development of a nomogram prediction model"],"prefix":"10.3389","volume":"16","author":[{"given":"Tingting","family":"Zou","sequence":"first","affiliation":[{"name":"School of Pharmacy, Shanxi Medical University","place":["Taiyuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xupeng","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shanxi Medical University","place":["Taiyuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixia","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shanxi Medical University","place":["Taiyuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuoran","family":"Li","sequence":"additional","affiliation":[{"name":"Shanxi Medical University","place":["Taiyuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Chai","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Shanxi Province Cancer Hospital\/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences\/Cancer Hospital Affiliated to Shanxi Medical University","place":["Taiyuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiying","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Shanxi Province Cancer Hospital\/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences\/Cancer Hospital Affiliated to Shanxi Medical University","place":["Taiyuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.4103\/ijmr.IJMR_857_20","article-title":"Screening for cervical cancer: choices and dilemmas","volume":"154","author":"Rajaram","year":"2021","journal-title":"Indian J Med Res"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol32030122","article-title":"HPV 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