{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:31:26Z","timestamp":1787725886991,"version":"build-2784847793"},"reference-count":8,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To analyze the endoscopic ultrasonography (EUS) features and clinical characteristics of gastric calcifying fibrous tumor (GCFT) to improve the endoscopic recognition of this entity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis was conducted on 20 consecutive patients with pathologically confirmed GCFT at Henan Provincial People\u2019s Hospital from January 2018 to May 2025. EUS findings and clinical data were reviewed to summarize the endoscopic and clinical features of this rare lesion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 20 patients, 12 (60.0%) were female, and 8 (40.0%) were male, with a mean age of 46.65 years (range: 29\u201362 years). Tumor size ranged from 0.5 to 2.8\u00a0cm, with a mean diameter of 1.18 \u00b1 0.55\u00a0cm. Most tumors were located in the gastric body (n = 16), followed by the fundus (n = 4). On computed tomography, most lesions presented as solid hyperdense nodules within the gastric wall. Endoscopically, all lesions appeared as submucosal tumors with smooth overlying mucosa. Preoperative EUS showed hypoechoic lesions in 19 cases and iso- to hypoechoic lesions in one. All originated from the muscularis propria. Hyperechoic foci, suggestive of calcifications, were observed in 13 lesions (central calcification in 1, peripheral in 12), accompanied by posterior acoustic shadowing. The overlying mucosa and submucosa appeared thickened compared to the surrounding normal layers. All patients underwent endoscopic resection. Histopathologically, tumors consisted of abundant hyalinized collagenous tissue with occasional calcifications and psammoma bodies. The Ki-67 index ranged from &amp;lt;1% to 5%, and immunohistochemical staining was negative for S-100, CD34, CD117, and Desmin. During a follow-up period of 5 to 71 months, no recurrence was observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>GCFT typically presents as a hypoechoic mass originating from the muscularis propria on EUS, frequently accompanied by calcification and deep echo attenuation. These features, when present, may suggest the diagnosis. Endoscopic resection is safe and effective for selected lesions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1835347","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:03:52Z","timestamp":1787724232000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["EUS features and clinical outcomes of gastric calcifying fibrous tumor: a retrospective analysis of 20 cases"],"prefix":"10.3389","volume":"16","author":[{"given":"Bing","family":"Bai","sequence":"first","affiliation":[{"name":"Oncology Center, Henan Provincial People\u2019s Hospital (People\u2019s Hospital of Zhengzhou University)","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Henan Provincial People\u2019s Hospital (People\u2019s Hospital of Zhengzhou University)","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingxi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Henan Provincial People\u2019s Hospital (People\u2019s Hospital of Zhengzhou University)","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baosong","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Henan Provincial People\u2019s Hospital (People\u2019s Hospital of Zhengzhou University)","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengli","family":"Kuang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Henan Provincial People\u2019s Hospital (People\u2019s Hospital of Zhengzhou University)","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000023334","article-title":"Gastric calcifying fibrous tumors","volume":"100","author":"Wang","year":"2021","journal-title":"Medicine"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000003690","article-title":"Calcifying fibrous tumor","volume":"95","author":"Chorti","year":"2016","journal-title":"Medicine"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000008882","article-title":"Calcifying fibrous tumor of stomach","volume":"96","author":"Li","year":"2017","journal-title":"Medicine"},{"key":"B4","doi-asserted-by":"publisher","first-page":"198","DOI":"10.18231\/j.ijpo.2023.042","article-title":"Endoscopic resection of gastric calcifying fibrous tumor: An incidental finding","volume":"10","author":"Chopra","year":"2023","journal-title":"Indian J Pathol Oncol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.17235\/reed.2023.9739\/2023","article-title":"A rare case of calcifying fibrous tumor and pathological analysis","volume":"116","author":"Cao","year":"2023","journal-title":"Rev Espa\u00f1ola Enfermedades Digestivas"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2018.6892","article-title":"Gastric calcifying fibrous tumor: A clinicopathological study of nine cases","volume":"16","author":"Tian","year":"2018","journal-title":"Exp Ther Med"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/5026860","article-title":"Clinicopathologic study of calcifying fibrous tumor emphasizing different anatomical distribution and favorable prognosis","volume":"2019","author":"Zhou","year":"2019","journal-title":"BioMed Res Int"},{"key":"B8","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1186\/s40792-019-0714-6","article-title":"Gastric calcifying fibrous tumor suspected to be complicated with immunoglobulin G4-related disease treated by laparoscopy and endoscopy cooperative surgery: a case report","volume":"5","author":"Hamura","year":"2019","journal-title":"Surg Case Rep"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1835347\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:03:53Z","timestamp":1787724233000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1835347\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,26]]},"references-count":8,"alternative-id":["10.3389\/fonc.2026.1835347"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2026.1835347","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,26]]},"article-number":"1835347"}}