{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:23:53Z","timestamp":1792167833508,"version":"4.4.0"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Gastric cancer recurrence commonly involves the peritoneum, liver, and lungs, whereas isolated intracranial metastasis is rare, particularly in patients receiving neoadjuvant therapy and surgery. This study aimed to characterize a distinct subgroup of patients with isolated intracranial recurrence after neoadjuvant treatment and radical surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed patients with gastric cancer who underwent neoadjuvant therapy followed by curative resection and subsequently developed isolated intracranial metastasis confirmed by whole\u2212body imaging. Clinical and pathological features were systematically analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twelve patients met the inclusion criteria. All patients were lymph node\u2212positive (100%). The primary tumor was located at the cardia or esophagogastric junction in 11 patients (91.7%). Poorly differentiated histology was observed in eight patients (66.7%), while the remaining four (33.3%) had moderately differentiated tumors; no well\u2212differentiated cases were identified. The median time from surgery to intracranial metastasis was 15.3 months (95% confidence interval: 9.0\u201321.6 months).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Isolated intracranial metastasis after neoadjuvant therapy for gastric cancer is associated with a distinct clinical profile: cardia\/esophagogastric junction location, positive lymph node status, and poorly differentiated histology. Recognition of this high\u2212risk profile may facilitate early diagnosis and inform surveillance strategies in this patient population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1838410","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T04:54:45Z","timestamp":1780030485000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Solitary intracranial metastasis as the sole relapse site in gastric cancer patients after neoadjuvant therapy and surgery: a case series of 12 patients and clinical implications"],"prefix":"10.3389","volume":"16","author":[{"given":"Weijie","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of General Surgery, the Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital","place":["Zhengzhou, Henan, 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