{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T05:09:21Z","timestamp":1779253761256,"version":"3.51.4"},"reference-count":18,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Early ampullary tumors are challenging to diagnose due to their complex surrounding structures and deep anatomical location. We report a rare case in which enhanced computed tomography (CT), magnetic resonance imaging (MRI), magnetic resonance cholangiopancreatography (MRCP) and endoscopic ultrasound (EUS) all failed to detect the lesion, with the diagnosis ultimately established through endoscopic retrograde cholangiopancreatography (ERCP). The patient subsequently underwent timely surgical resection. This case highlights the irreplaceable value of ERCP in detecting early and occult ampullary tumors.<\/jats:p>","DOI":"10.3389\/fonc.2026.1840198","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T04:33:58Z","timestamp":1779251638000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Ampullary carcinoma detected incidentally during ERCP: a case report and literature review"],"prefix":"10.3389","volume":"16","author":[{"given":"Heyue","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of First General Surgery, The Sixth People\u2019s Hospital of Shenyang","place":["Shenyang, Liaoning, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of First General Surgery, The Sixth People\u2019s Hospital of Shenyang","place":["Shenyang, Liaoning, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of First General Surgery, The Sixth People\u2019s Hospital of Shenyang","place":["Shenyang, Liaoning, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1186\/s13256-021-02674-z","article-title":"Biliary type-II sphincter of Oddi dysfunction with a pancreatic duct dilation: a case report and review of the literature","volume":"15","author":"Al-Khoury","year":"2021","journal-title":"J Med Case Rep"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13193138","article-title":"Updates on the management of ampullary neoplastic lesions","volume":"13","author":"Maselli","year":"2023","journal-title":"Diag Bsl"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.17235\/reed.2024.10567\/2024","article-title":"Acute pancreatitis as the initial manifestation of an ampullary neuroendocrine tumor","volume":"117","author":"Mu\u00ed\u00f1o Dom\u00ednguez","year":"2025","journal-title":"Rev Esp Enferm Dig"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics14171855","article-title":"The role of endoscopic ultrasound in ampullary lesion management","volume":"14","author":"Stornello","year":"2024","journal-title":"Diag Bsl"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2022.2067785","article-title":"Diagnostic accuracy of endoscopic ultrasound and intraductal ultrasonography for assessment of ampullary tumors: a meta-analysis","volume":"57","author":"Ye","year":"2022","journal-title":"Scand J Gastroenterol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1055\/a-1397-3198","article-title":"Endoscopic management of ampullary tumors: European Society of Gastrointestinal Endoscopy (ESGE) Guideline","volume":"53","author":"Vanbiervliet","year":"2021","journal-title":"Endoscopy"},{"key":"B7","doi-asserted-by":"publisher","first-page":"186","DOI":"10.4103\/EUS-D-21-00106","article-title":"Controversies in ERCP: indications and preparation","volume":"11","author":"Dietrich","year":"2022","journal-title":"Endosc Ultrasound"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.55729\/2000-9666.1298","article-title":"The diagnostic yield of endoscopic ultrasound in asymptomatic patients with unexplained dilated common bile duct, or double duct sign with normal transaminase a retrospective study from a single urban-based university endoscopy center","volume":"14","author":"Alkomos","year":"2024","journal-title":"J Community Hosp Intern Med Perspect"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.14701\/ahbps.23-063","article-title":"Incidental double duct sign: Should we be worried? 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