{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:35:23Z","timestamp":1792017323231,"version":"4.4.0"},"reference-count":103,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Prostate cancer (PCa) is a leading malignancy in men, with mortality primarily attributed to progression to castration-resistant prostate cancer (CRPC). Although androgen deprivation therapy (ADT) initially demonstrates efficacy, most advanced patients eventually develop CRPC\u2014a stage characterized by limited treatment options and poor prognosis. Elucidating the molecular mechanisms underlying CRPC transformation therefore represents a research priority. Tumor metabolic reprogramming has emerged as a hallmark of cancer, and among various metabolic pathways, lysophosphatidic acid (LPA)\u2014a bioactive lipid mediator\u2014has been increasingly implicated in PCa progression, particularly CRPC transformation. This review systematically examines LPA metabolic sources and signal transduction mechanisms and explores how LPA promotes CRPC progression through driving proliferation, survival, invasion, therapy resistance, and tumor microenvironment remodeling. Finally, we discuss the potential and challenges of targeting the LPA signaling pathway as a novel therapeutic strategy for CRPC.<\/jats:p>","DOI":"10.3389\/fonc.2026.1842091","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T04:57:37Z","timestamp":1779425857000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["The role of lysophosphatidic acid metabolism in castration-resistant prostate cancer progression"],"prefix":"10.3389","volume":"16","author":[{"given":"Jinpeng","family":"Feng","sequence":"first","affiliation":[{"name":"Jiaxing University Master Degree Cultivation Base, Zhejiang Chinese Medical University","place":["Hangzhou, China"]},{"name":"Department of Urology, The Afffliated Hospital of Jiaxing University","place":["Jiaxing, 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