{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T05:04:20Z","timestamp":1789535060041,"version":"build-2803163510"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Postoperative recovery and venous thromboembolism (VTE) are major concerns following total laparoscopic hysterectomy (TLH). This study aimed to evaluate the impact of a multimodal prehabilitation program on postoperative recovery and its clinical effects on reducing VTE risk in patients undergoing TLH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study involved 274 patients who underwent TLH for benign uterine diseases. Patients were divided into a conventional group (n = 145) and a prehabilitation group (n = 129). Postoperative recovery indicators, Caprini risk scores, lower extremity deep vein thrombosis (DVT) incidence, serum markers (coagulation function and inflammatory parameters), and complications were compared between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with the conventional group, patients in the prehabilitation group demonstrated significantly shorter times to first anal exhaust (22.63 \u00b1 4.38 vs. 24.47 \u00b1 5.44\u00a0h, P\u00a0=\u00a00.002), first bowel movement (61.08 \u00b1 6.23 vs. 63.26 \u00b1 7.21\u00a0h, P\u00a0=\u00a00.008), first ambulation (18.45 \u00b1 3.74 vs. 22.34 \u00b1 4.09\u00a0h, P &amp;lt; 0.001), and postoperative hospital stay (4.39 \u00b1 0.71 vs. 6.95 \u00b1 1.03 days, P &amp;lt; 0.001). Postoperative pain scores at 6, 24, and 48\u00a0h were also significantly lower in the prehabilitation group (all P &amp;lt; 0.05). Additionally, the prehabilitation group showed improved postoperative Caprini risk profiles (P &amp;lt; 0.001) and significantly lower incidence of lower-extremity DVT (2.33% vs. 14.48%, P &amp;lt; 0.001). Coagulation function and inflammatory markers were also significantly improved in the prehabilitation group. Multivariate analysis further identified the prehabilitation program as an independent protective factor against postoperative DVT (OR\u00a0=\u00a00.223, 95%CI: 0.099\u20130.502, P &amp;lt; 0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Multimodal prehabilitation significantly enhances postoperative recovery and reduces the risk of venous thromboembolism in patients undergoing TLH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1842401","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T04:30:48Z","timestamp":1789533048000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of a multimodal prehabilitation program on postoperative recovery in patients undergoing total laparoscopic hysterectomy and its clinical effects on reducing the risk of venous thromboembolism occurrence"],"prefix":"10.3389","volume":"16","author":[{"given":"Liuhua","family":"Qu","sequence":"first","affiliation":[{"name":"Department of Gynaecology, Ningyuan County People\u2019s Hospital","place":["Yongzhou, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Ningyuan County People\u2019s Hospital","place":["Yongzhou, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Ningyuan County People\u2019s Hospital","place":["Yongzhou, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14415","article-title":"Comparison of the effects of laparoscopic and open 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