{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:16:55Z","timestamp":1783487815266,"version":"3.55.0"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>Rosai-Dorfman Disease (RDD) is a rare form of sinus histiocytosis characterized by massive lymphadenopathy, commonly involving lymph nodes and occurring more frequently in children and young adults. Extranodal involvement of the breast is particularly uncommon. Here, we report a rare case of breast RDD, detailing the clinical findings, diagnostic process, and treatment, accompanied by a review of relevant literature. Given the limited cases of breast RDD reported, there is no established consensus on its diagnosis and treatment. This article aims to enhance understanding of breast RDD and inform clinical management practices.<\/jats:p>","DOI":"10.3389\/fonc.2026.1844736","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:47:09Z","timestamp":1783486029000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Rosai-Dorfman disease in the breast: a case report and literature review"],"prefix":"10.3389","volume":"16","author":[{"given":"Manqing","family":"Cao","sequence":"first","affiliation":[{"name":"The Second Surgical Department of Breast Cancer, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer","place":["Tianjin, China"]},{"name":"Tianjin\u2019s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Key Laboratory of Cancer Prevention and Therapy","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Breast and Thyroid Surgery, The People's Hospital of the Qiandongnan Miao and Dong Autonomous Prefecture","place":["Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Breast Pathology and Lab, Tianjin Medical University Cancer Institute & Hospital","place":["Tianjin, China"]},{"name":"Tianjin\u2019s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Key Laboratory of Cancer Prevention and Therapy","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tianjin Medical University Cancer Institute & Hospital","place":["Tianjin, China"]},{"name":"Tianjin\u2019s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Key Laboratory of Cancer Prevention and Therapy","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangsheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Breast Imaging, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer","place":["Tianjin, China"]},{"name":"Tianjin\u2019s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Key Laboratory of Cancer Prevention and Therapy","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Liu","sequence":"additional","affiliation":[{"name":"The Second Surgical Department of Breast Cancer, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer","place":["Tianjin, China"]},{"name":"Tianjin\u2019s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Key Laboratory of Cancer Prevention and Therapy","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Wang","sequence":"additional","affiliation":[{"name":"The Second Surgical Department of Breast Cancer, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer","place":["Tianjin, China"]},{"name":"Tianjin\u2019s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Key Laboratory of Cancer Prevention and Therapy","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"B1","first-page":"63","article-title":"Sinus histiocytosis with massive lymphadenopathy. 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