{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T05:36:44Z","timestamp":1782970604392,"version":"3.54.5"},"reference-count":14,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:p>This article reports a case of Spitz nevus with ALK positive nasal cavity in a 3-year-old and 5-month-old female child. The clinical manifestation is red patches on the nose of the child, gradually increasing in size, without itching or pain. Histopathological examination showed a large proliferation of spindle shaped cells in the dermis, without any evidence of nuclear fission. Spindle shaped cells show positive reactions to markers such as S100, SOX10, ALK, P16, MelanA, etc. Pathological diagnosis of Spitz nevus with ALK positivity. Spitz nevus is a benign proliferative lesion of melanocytes, commonly found in children and adolescents, with specific clinical and pathological features. ALK gene fusion is more common in Spitz nevi and helps in differential diagnosis from malignant melanoma. Most ALK positive Spitz nevi exhibit benign biological behavior, but close follow-up is still necessary to assess potential risks. Future research should further explore the relationship between fusion genes and the biological behavior of Spitz tumors.<\/jats:p>","DOI":"10.3389\/fonc.2026.1845068","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T04:24:22Z","timestamp":1782966262000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["ALK-positive Spitz nevus of the nasal dorsum in a child: a case report and literature review"],"prefix":"10.3389","volume":"16","author":[{"given":"Wang","family":"Juan","sequence":"first","affiliation":[{"name":"Southwest Hospital, Army Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifang","family":"Zhai","sequence":"additional","affiliation":[{"name":"Southwest Hospital, Army Medical University","place":["Chongqing, 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