{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T05:02:31Z","timestamp":1785301351542,"version":"3.55.0"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study analyzes the therapeutic efficacy of hypopharyngeal cancer following laryngeal function-preserving surgery, assesses the recovery of swallowing and vocal functions, provides a reference for the selection of surgical approaches and the implementation of postoperative rehabilitation training for swallowing and vocal functions, and thereby improves the therapeutic outcomes and quality of life of patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Date from 23 patients with hypopharyngeal carcinoma who underwent laryngeal function-preserving surgery at the Department of Otorhinolaryngology Head and Neck Surgery between January 2017 and January 2024 were retrospectively analyzed in February 2025. The Kaplan-Meier method was employed to calculate the 1-, 3-, and 5-year disease-free survival (DFS) and overall survival (OS) rates. Intergroup differences were compared using the log-rank test, and the COX proportional hazards regression model was applied to identify key prognostic risk factors. Swallowing function and swallowing-related quality of life were assessed via a combination of flexible endoscopic evaluation of swallowing (FEES) and the M.D. Anderson Dysphagia Inventory (MDADI) scale. Voice function and voice-related quality of life were comprehensively evaluated using acoustic parameters (shimmer, jitter, fundamental frequency [F0]), maximum phonation time (MPT) measurements, and the 10-Item Voice Handicap Index (VHI-10). Spearman\u2019s rank correlation analysis was used to explore the factors influencing postoperative swallowing and voice rehabilitation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The 1-, 3-, and 5-year OS rates were 87.51%, 53.33%, and 42.86%, respectively, while the corresponding 1-, 3-, and 5-year DFS rates were 71.93%, 46.72%, and 42.86%. Lymph node metastasis reduced OS (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&amp;lt;\u00a00.05). FEES showed texture-dependent pharyngeal residue, rare solid-food aspiration but frequent laryngeal penetration for semi-liquids and liquids. Vocal acoustic\/aerodynamic parameters and favorable MDADI (84.17\u00a0\u00b1\u00a012.18) and VHI-10 (10.17\u00a0\u00b1\u00a08.18) scores were recorded in 23 functional-assessed patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Laryngeal function-preserving surgery yields satisfactory oncological outcomes for hypopharyngeal carcinoma patients, Most patients achieved acceptable swallowing and voice function with good quality of life. This surgical approach effectively balances oncological efficacy and preserves organ function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fonc.2026.1848440","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T04:35:59Z","timestamp":1785299759000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Analysis of clinical efficacy and quality of life in hypopharyngeal cancer patients undergoing laryngeal-preserving surgery"],"prefix":"10.3389","volume":"16","author":[{"given":"Jie","family":"Deng","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, The Ziyang Central Hospital","place":["Ziyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengen","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, The Affiliated Hospital of Southwest Medical University","place":["Luzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huajun","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, The Affiliated Hospital of Southwest Medical University","place":["Luzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, The Affiliated Hospital of Southwest Medical University","place":["Luzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23867","article-title":"Swallowing function in patients with vertical hemipharyngolaryngectomy for hypopharyngeal squamous cell carcinoma","volume":"38","author":"Joo","year":"2016","journal-title":"Head Neck"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26734","article-title":"Supracricoid partial laryngectomy with cricohyoidoepiglottopexy for patients with laryngeal cicatricial stenosis: Safety and efficacy","volume":"43","author":"Yu","year":"2021","journal-title":"Head Neck"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol30120753","article-title":"Head and neck cancer: A study on the complex relationship between QoL and swallowing function","volume":"30","author":"Str\u00fcder","year":"2023","journal-title":"Curr Oncol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25487","article-title":"Long-term changes in vocal function after supracricoid partial laryngectomy with cricohyoidoepiglottopexy for laryngeal cancer","volume":"41","author":"Miyamaru","year":"2019","journal-title":"Head Neck"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.12.036","article-title":"Laryngeal function after supracricoid laryngectomy","volume":"140","author":"Saito","year":"2009","journal-title":"Otolaryngol Head Neck Surg"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1177\/000348941212100608","article-title":"Multidimensional evaluation of vocal function after supracricoid laryngectomy with cricohyoidopexy","volume":"121","author":"Topalo\u011flu","year":"2012","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1097\/00005537-199905000-00004","article-title":"Vocal function after vertical partial laryngectomy with glottic reconstruction by false vocal fold flap: durational and frequency measures","volume":"109","author":"Biacabe","year":"1999","journal-title":"Laryngoscope"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2007.04.004","article-title":"Multidimensional assessment of voice after vertical partial laryngectomy: a comparison with normal and total laryngectomy voice","volume":"22","author":"Singh","year":"2008","journal-title":"J Voice"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-020-06718-8","article-title":"Comparison of diagnostic performance between CT and MRI for detection of cartilage invasion for primary tumor staging in patients with laryngo-hypopharyngeal cancer: a systematic review and meta-analysis","volume":"30","author":"Cho","year":"2020","journal-title":"Eur Radiol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.676","article-title":"Predictors of severe dysphagia following radiotherapy for head and neck cancer","volume":"6","author":"Petersson","year":"2021","journal-title":"Laryngoscope Investig Otolaryngol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2006.01.010","article-title":"Long-term voice and swallowing modifications after supracricoid laryngectomy: objective, subjective, and self-assessment data","volume":"27","author":"Schindler","year":"2006","journal-title":"Am J Otolaryngol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1177\/0194599811416438","article-title":"Quality of voice evaluation in patients treated by supracricoid laryngectomy and modified supracricoid laryngectomy","volume":"145","author":"Allegra","year":"2011","journal-title":"Otolaryngol Head Neck Surg"},{"key":"B13","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1002\/lio2.351","article-title":"Systematic review and meta-analysis of transoral laser microsurgery in hypopharyngeal carcinoma","volume":"5","author":"Lane","year":"2020","journal-title":"Laryngoscope Investig Otolaryngol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1186\/s12885-017-3396-0","article-title":"Clinical outcomes of transoral videolaryngoscopic surgery for hypopharyngeal and supraglottic cancer","volume":"17","author":"Imanishi","year":"2017","journal-title":"BMC Cancer"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.1068","article-title":"Salvage transoral videolaryngoscopic surgery for post-irradiation recurrence of hypopharyngeal carcinoma","volume":"8","author":"Sakai","year":"2023","journal-title":"Laryngoscope Investig Otolaryngol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2019.09.003","article-title":"Transoral videolaryngoscopic surgery for laryngeal and hypopharyngeal cancer - Technical updates and long-term results","volume":"47","author":"Tomifuji","year":"2020","journal-title":"Auris Nasus Larynx"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.287","article-title":"Single-port versus multiport da Vinci system for transoral robotic surgery of hypopharyngeal and laryngeal carcinoma","volume":"169","author":"Sampieri","year":"2023","journal-title":"Otolaryngol Head Neck Surg"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2021.01.024","article-title":"Treatment outcomes of transoral robotic and non-robotic surgeries to treat oropharyngeal, hypopharyngeal, and supraglottic squamous cell carcinoma: A multi-center retrospective observational study in Japan","volume":"48","author":"Sano","year":"2021","journal-title":"Auris Nasus Larynx"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1002\/hed.27634","article-title":"Transoral robotic vertical partial laryngectomy (hemilaryngectomy) extended to the hypopharynx","volume":"46","author":"Meliante","year":"2024","journal-title":"Head Neck"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14133146","article-title":"Oncological analysis and surgical outcomes in postcricoid carcinoma: A 14 years retrospective study","volume":"14","author":"Chen","year":"2022","journal-title":"Cancers (Basel)"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-23-2398","article-title":"Induction toripalimab and chemotherapy for organ preservation in locally advanced laryngeal and hypopharyngeal cancer: A single-arm phase II clinical trial","volume":"30","author":"Ou","year":"2024","journal-title":"Clin Cancer Res"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3390\/medicina59101873","article-title":"The role of open conservation surgery in the era of minimally invasive surgery for hypopharyngeal cancer","volume":"59","author":"Bang","year":"2023","journal-title":"Med (Kaunas)"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29186","article-title":"Predicting factors for oncological and functional outcome in hypopharyngeal cancer","volume":"131","author":"Visini","year":"2021","journal-title":"Laryngoscope"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1186\/s12885-022-10172-8","article-title":"Prognostic impact of the number of metastatic lymph nodes after surgery in locally advanced hypopharyngeal cancer","volume":"22","author":"Nishimura","year":"2022","journal-title":"BMC Cancer"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1177\/01455613211058108","article-title":"Survival and swallowing function outcome impact factors analysis of surgery-oriented comprehensive treatment for hypopharyngeal cancer in a series of 122 patients","volume":"101","author":"Li","year":"2022","journal-title":"Ear Nose Throat J"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-020-06460-3","article-title":"Results of pretreatment swallowing evaluation in patients with stage III\/IV laryngeal and hypopharyngeal carcinoma","volume":"278","author":"Balaji","year":"2021","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2022.879830","article-title":"Risk stratification of dysphagia after surgical treatment of hypopharyngeal cancer","volume":"9","author":"Joo","year":"2022","journal-title":"Front Surg"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000157848.78530.ee","article-title":"Acoustic and aerodynamic measurement of speech production after supracricoid partial laryngectomy","volume":"115","author":"Makeieff","year":"2005","journal-title":"Laryngoscope"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1848440\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T04:36:04Z","timestamp":1785299764000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2026.1848440\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,29]]},"references-count":28,"alternative-id":["10.3389\/fonc.2026.1848440"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2026.1848440","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,29]]},"article-number":"1848440"}}